ArticleCurrent issues in molecular biology2026
Survival-Associated Molecular and Epigenetic Alterations in Endocervical Adenocarcinoma: An Exploratory TCGA Multi-Omics Cohort Study.
Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
objectiveThe objective of this exploratory study was to identify the molecular characteristics that influence survival outcomes in cases of cervical adenocarcinoma, utilising data from the TCGA (The Cancer Genome Atlas) database.
methodsThe 'TCGA Firehose Legacy' dataset was accessed through the Cbioportal website. SILVA invasion patterns were independently evaluated on digitized whole-slide images by two gynecologic pathologists. Cases were categorized by overall survival status (living vs. deceased). Somatic mutations, copy number alterations, mRNA expression, RPPA protein expression, and DNA methylation profiles were analyzed. Survival analyses were performed using Kaplan-Meier methods and log-rank tests, supplemented by differential analysis. Pathway and transcription factor binding motif enrichment was evaluated via g:Profiler.
resultsAmong 27 cases (22 living, 5 deceased; 23 HPV-positive, 2 HPV-negative, 2 unknown), PREX1 protein expression was identified as the top-ranked differentially expressed candidate protein (
conclusionsIn this exploratory cohort, elevated PREX1 protein levels and promoter hypermethylation of specific immune- and metabolic-related genes were associated with overall survival in endocervical adenocarcinoma. Due to the current lack of independent public proteomic validation datasets, PREX1 emerges as a novel candidate biomarker requiring prospective tissue-based immunohistochemical and epigenetic validation in larger multi-center clinical cohorts.
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