Targeting Nuclear Import of Thyroid Hormone Receptor Alpha with Natural Polyphenols: Potential Mechanism for Lipolysis in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Evangelia K Konstantinou, Athanasios A Panagiotopoulos, Maria Dimitriou, Elias Castanas

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Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Evangelia K KonstantinouDepartment of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, Greece.

Athanasios A PanagiotopoulosDepartment of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, Greece.ORCID 0000-0002-8015-0484

Maria DimitriouDepartment of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, Greece.ORCID 0000-0002-8469-8068

Elias CastanasLaboratory of Experimental Endocrinology, School of Medicine, University of Crete, Voutes Campus, 71013 Heraklion, Greece.ORCID 0000-0002-8370-1835

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by excessive liver lipids and metabolic imbalance. Thyroid hormone receptor alpha (THRA) is essential for liver lipolysis; however, its transcription function is dependent on successful nuclear localization. Since natural polyphenols are known to modulate THRA activity, making them potential candidates for MASLD management, their roles in THRA nuclear trafficking have not been elucidated. In this study, an integrative computational method was utilized to investigate the impact of polyphenol binding on THRA nuclear import. Protein-protein docking simulations suggested that polyphenol binding may augment the interaction of THRA and importin-α, while importin-7 was predicted to be essential for basal transport. In conclusion, our findings showed that polyphenol binding could potentially support THRA nuclear import, thus potentially implicating a new process in MASLD.

Indexed as

importinsmetabolic dysfunction-associated steatotic liver disease (MASLD)nuclear importpolyphenolsthyroid hormone receptor alpha (THRA)

Identifiers

PMID42793229

DOI10.3390/cimb48090873

PMCPMC13605495

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.