ArticleBiomolecules2026
Integrative Transcriptomics Reveals a Mitochondria-Related Gene Signature in Periodontitis.
Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Mitochondrial dysfunction contributes to periodontal inflammation and tissue destruction, yet the mitochondria-related transcriptional changes associated with periodontitis remain incompletely characterized. Using an integrative bioinformatics study design with experimental validation in cellular and animal models, we sought to identify a mitochondria-related gene signature in affected periodontal tissues and evaluate selected candidates experimentally. Differential expression analysis and weighted gene co-expression network analysis of GSE16134 were integrated with MitoCarta3.0 annotation. Candidate genes were evaluated using 101 feature-selection and classification combinations across GSE16134, GSE10334, GSE33774, and GSE173078, followed by functional enrichment, pathway-level analysis, and immune-cell deconvolution. Selected candidates were assessed by reverse-transcription quantitative polymerase chain reaction in lipopolysaccharide-stimulated RAW 264.7 macrophages and by immunohistochemistry in a ligature-induced rat periodontitis model. The integrated analysis identified 25 candidate genes. A backward stepwise generalized linear model combined with random forest selected
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