Evidence map›Paper›PMID 42793198›Full record

ArticleBiomolecules2026

DISC1 Orchestrates Mitochondrial Calcium Overload in Diabetic Encephalopathy Through a Dual Nucleocytoplasmic Mechanism.

Lu He, Hao Li, Rui Yin, Liangli Dai, Weijian Hang, Yong Liu, Man Li, Tao Liang, Yumei Wang, Juan Chen

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lu HeDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Hao LiKey Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Rui YinDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Liangli DaiDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Weijian HangDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yong LiuDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Man LiKey Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0003-4041-0437
Tao LiangDepartment of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yumei WangDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Juan ChenDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Funding

National Natural Science Foundation of China 82370837National Natural Science Foundation of China 82570859
6 · The paper itself

Abstract

Hyperglycemia-driven mitochondrial dysfunction is a primary driver of diabetic encephalopathy (DE). Here, we identify a novel nucleocytoplasmic "dual effect" of DISC1 that coordinates mitochondrial Ca

Indexed as

CalciumCell NucleusMitochondriaNerve Tissue ProteinsAnimalsBrain DiseasesCytoplasmEndoplasmic ReticulumGlucoseHSP70 Heat-Shock ProteinsHumansHypoglycemiaMembrane ProteinsMitochondrial ProteinsCalciumDISC1 protein, humanGlucoseglucose-regulated proteinsHSP70 Heat-Shock ProteinsMembrane ProteinsMitochondrial ProteinsNerve Tissue Proteinsdiabetic encephalopathyDISC1GRP75mitochondrionnuclear localization

Identifiers

PMID42793198
PMCPMC13604470

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.