In Vitro Antioxidant Activity and Dual-Target Inhibitory Effects of Dipyridamole on α-Amylase and α-Glucosidase: Molecular Mechanisms and Molecular Dynamics Simulations.

Cong Zhao, Hongfei Liu, Yuting Shu, Jingchen Wei, Ruiqian Feng, Lina Chen, Helong Bai, Jing Wang, Dongfang Shi

Abstract read

In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cong ZhaoCollege of Life Sciences, Changchun Normal University, Changchun 130032, China.

Hongfei LiuCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Yuting ShuCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Jingchen WeiCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Ruiqian FengCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Lina ChenCollege of Chemistry, Changchun Normal University, Changchun 130032, China.

Helong BaiCollege of Chemistry, Changchun Normal University, Changchun 130032, China.ORCID 0009-0006-7988-9202

Jing WangCollege of Life Sciences, Changchun Normal University, Changchun 130032, China.

Dongfang ShiInstitute of Science and Technology Innovation, Changchun Normal University, Changchun 130032, China.

Funding

Changchun Normal University CSJJ2025003ZK

6 · The paper itself

Abstract

α-Amylase and α-glucosidase are complementary therapeutic targets in type 2 diabetes; simultaneous inhibition provides a dual-blockade strategy to suppress postprandial hyperglycemia. Dipyridamole, a conventional antiplatelet drug with proven anti-inflammatory, antioxidant, and antiproliferative effects and a favorable safety profile, is a candidate for repurposing. This study assessed in vitro antioxidant activity and inhibitory actions against both enzymes, and employed molecular docking, molecular dynamics simulations to elucidate mechanisms. Dipyridamole showed EC

Indexed as

alpha-Amylasesalpha-GlucosidasesAntioxidantsDipyridamoleGlycoside Hydrolase InhibitorsMolecular Dynamics SimulationHydrogen BondingMolecular Docking Simulationalpha-Amylasesalpha-GlucosidasesAntioxidantsDipyridamoleGlycoside Hydrolase Inhibitorsantioxidantdipyridamoleα-amylaseα-glucosidase

Identifiers

PMID42793193

DOI10.3390/biom16091361

PMCPMC13604823

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.