Evidence map›Paper›PMID 42793187›Full record

ArticleBiomolecules2026

Comparing YAP

Clara Merlen, Yannick Mesrouze, Suzanne Chau, Benjamin A Diehl, Alexandra Hinniger, Catherine Zimmermann, Marco Meyerhofer, Patrizia Fontana, Svenya Groebke, Jürgen Hinrichs and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Clara MerlenOncology Disease Area, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Yannick MesrouzeOncology Disease Area, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Suzanne ChauDiscovery Sciences, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Benjamin A DiehlGlobal Discovery Chemistry, Novartis Biomedical Research, CH-4056 Basel, Switzerland.ORCID 0009-0002-2628-7268
Alexandra HinnigerDiscovery Sciences, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Catherine ZimmermannOncology Disease Area, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Marco MeyerhoferOncology Disease Area, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Patrizia FontanaOncology Disease Area, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Svenya GroebkeOncology Disease Area, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Jürgen HinrichsGlobal Discovery Chemistry, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Wassim Abdul RahmanOncology Disease Area, Novartis Biomedical Research, CH-4056 Basel, Switzerland.ORCID 0000-0002-9069-5293
Sascha GutmannDiscovery Sciences, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
César FernándezDiscovery Sciences, Novartis Biomedical Research, CH-4056 Basel, Switzerland.
Dušan PetrovićGlobal Discovery Chemistry, Novartis Biomedical Research, CH-4056 Basel, Switzerland.ORCID 0000-0002-1834-7358
Patrick ChèneOncology Disease Area, Novartis Biomedical Research, CH-4056 Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The two paralogs YAP and TAZ act through TEAD transcription factors and bind PPxY motif proteins in the Hippo pathway via WW domains. YAP has up to two WW domains, whereas TAZ has one. Because YAP

Indexed as

Adaptor Proteins, Signal TransducingTranscription FactorsBinding SitesHumansMolecular Dynamics SimulationProtein BindingProtein ConformationProtein StabilityTrans-ActivatorsWW DomainsYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingTrans-ActivatorsTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinsconformational flexibilitymolecular recognitionPPxY motifTAZWW domainYAP

Identifiers

PMID42793187
PMCPMC13604635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.