Dystrophin Deficiency Creates a Pro-Ferroptotic Environment in Diaphragm of mdx Mice That Is Modified by Diet and Glucocorticoid Treatment.

Morgan E Vorwald, Melissa Roths, Rudy J Valentine, Joshua T Selsby

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Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Morgan E VorwaldDepartment of Animal Science, Iowa State University, 806 Stange Rd., Kildee Hall, Ames, IA 50010, USA.ORCID 0009-0001-0242-7687

Melissa RothsDepartment of Animal Science, Iowa State University, 806 Stange Rd., Kildee Hall, Ames, IA 50010, USA.ORCID 0000-0001-8814-9130

Rudy J ValentineDepartment of Physical Therapy and Kinesiology, University of Massachusetts Lowell, 114 Wilder Street, Suite 300, Lowell, MA 01854, USA.ORCID 0000-0003-4915-6615

Joshua T SelsbyDepartment of Animal Science, Iowa State University, 806 Stange Rd., Kildee Hall, Ames, IA 50010, USA.ORCID 0000-0003-3797-7539

Funding

Muscular Dystrophy Association 962344

6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting with altered iron homeostasis and dysregulated lipid metabolism. Insulin resistance and obesity are common in DMD, but their impact on disease progression, particularly during glucocorticoid (GC) treatment, remains unclear. The role of ferroptosis, iron-dependent cell death, in DMD muscle pathology remains uncertain. We hypothesized that ferroptotic signaling would increase in mdx skeletal muscle, be further exacerbated by a high-fat, high-sucrose diet (HFHSD), and be attenuated by GC treatment. Male C57 and mdx mice were fed a control diet or HFHSD, with or without prednisolone, for 19 weeks before diaphragm western blot analysis. Dystrophic diaphragms had an increased abundance of transferrin (131%,

Indexed as

DiaphragmDystrophinFerroptosisGlucocorticoidsMuscular Dystrophy, DuchenneAnimalsDiet, High-FatIronMaleMiceMice, Inbred C57BLMice, Inbred mdxMuscle, SkeletalOxidative StressPhospholipid Hydroperoxide Glutathione PeroxidaseDystrophinGlucocorticoidsIronPhospholipid Hydroperoxide Glutathione PeroxidaseDuchenne muscular dystrophyferroptosismdxmuscleoxidative stress

Identifiers

PMID42793179

DOI10.3390/biom16091347

PMCPMC13604109

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.