Evidence map›Paper›PMID 42793175›Full record

ArticleBiomolecules2026

Determinants of C

Madeline S Childress, Kristen A Jeffries, Sergey A Krupenko, Natalia I Krupenko

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madeline S ChildressNutrition Research Institute, UNC-Chapel Hill, Kannapolis, NC 28081, USA.ORCID 0009-0009-9608-7676
Kristen A JeffriesNutrition Research Institute, UNC-Chapel Hill, Kannapolis, NC 28081, USA.
Sergey A KrupenkoDepartment of Nutrition, UNC-Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-6926-2776
Natalia I KrupenkoDepartment of Nutrition, UNC-Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-2977-1557

Funding

Ceramide signaling in the regulation of cellular response to folate stressR01CA193782 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KRUPENKO, NATALIA IVANOVNA · 2015 to 2019
$1.7M
NCI NIH HHS R01 CA193782NIH HHS 1R01CA193782-01A1UNC Nutrition Research Institute
6 · The paper itself

Abstract

The tumor suppressor p53 coordinates cellular stress responses, but underlying mechanisms remain incompletely understood. We previously demonstrated that, in response to metabolic stress, C

Indexed as

CeramidesTumor Suppressor Protein p53Binding SitesEndoplasmic ReticulumHumansMutationOxidoreductasesProtein BindingSphingosine N-AcyltransferaseCeramidesdihydroceramide desaturaseN-palmitoylsphingosineOxidoreductasesSphingosine N-AcyltransferaseTP53 protein, humanTumor Suppressor Protein p53C16-ceramideCerS6ER stressmutant p53p53 activationsphingolipid signaling

Identifiers

PMID42793175
PMCPMC13604752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.