Evidence map›Paper›PMID 42793160›Full record

ArticleBiomolecules2026

Mechanism of Synergistic Action of Isochlorogenic Acid C and Ciprofloxacin Against Drug-Resistant

Yubin Bai, Xu Chen, Rongbin Hu, Xun Gao, Xiaojuan Wei, Zixuan Shang, Jiyu Zhang, Zhen Zhu, Mingze Cao, Bing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yubin BaiKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.ORCID 0000-0002-6855-8524
Xu ChenKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.
Rongbin HuKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.
Xun GaoKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.
Xiaojuan WeiKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.
Zixuan ShangKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.
Jiyu ZhangKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.
Zhen ZhuSchool of Life Science and Food Engineering, Hebei University of Engineering, Handan 056038, China.
Mingze CaoSchool of Life Science and Food Engineering, Hebei University of Engineering, Handan 056038, China.
Bing LiKey Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development of the Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China.

Funding

Chinese Academy of Agricultural Sciences 1610322026005Chinese Academy of Agricultural Sciences 1610322026017Chinese Academy of Agricultural Sciences 1610322026042Chinese Academy of Agricultural Sciences CAAS-ASTIP-2014-LIHPSGansu Provincial Science and Technology Department 23ZDFA001Hebei Provincial Department of Science and Technology C2024402032Ministry of Agriculture and Rural Affairs CARS-37
6 · The paper itself

Abstract

backgroundThe rapid emergence of antibiotic resistance in

methodsWe screened ten antibiotics in combination with isochlorogenic acid C (ICAC) against multidrug-resistant (MDR)

resultsICAC exerted a specific synergistic effect with ciprofloxacin, significantly enhancing its efficacy. The combination disrupted bacterial membrane and cell wall integrity, increased permeability, and inhibited ATP synthesis. Mechanistically, ICAC may target OmpF and inhibit fatty acid biosynthesis. This interference reduced β-oxidation and the influx of acetyl-CoA into the TCA cycle, thereby impairing bacterial energy metabolism and destabilizing the membrane. In vivo validation using a mouse peritonitis model confirmed that the combination treatment effectively alleviated systemic

conclusionICAC may potentiate the antibacterial activity of ciprofloxacin through targeting of OmpF, which disrupts bacterial membrane integrity and energy metabolism, providing a promising candidate strategy for combating infections caused by the tested antibiotic-resistant

Indexed as

Anti-Bacterial AgentsCiprofloxacinDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsAnimalsDrug SynergismEscherichia coli ProteinsFemaleMiceMice, Inbred BALB CMicrobial Sensitivity TestsMolecular Docking SimulationAnti-Bacterial AgentsCiprofloxacinEscherichia coli ProteinsCiprofloxacinEscherichia coliICACmechanismsynergistic effect

Identifiers

PMID42793160
PMCPMC13604192

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.