CXCL10 Is Inhibited by PPARβ/δ-Selective Activation in Human Monocyte-Derived Dendritic Cells, T Lymphocytes and Monocytes In Vitro: Insights into Autoimmune Rheumatic Diseases.

Gabriele Farina, Mariangela Sottili, Giada La Spina, Stefania Gelmini, Simona Truglia, Fabrizio Conti, Francesca Romana Spinelli, Clara Crescioli

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Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriele FarinaDepartment of Movement, Human and Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy.

Mariangela SottiliDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50121 Florence, Italy.

Giada La SpinaDepartment of Internal Medicine and Medical Specialties, AOU Policlinico Umberto I, 00185 Rome, Italy.ORCID 0009-0006-5662-5554

Stefania GelminiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50121 Florence, Italy.

Simona TrugliaDepartment of Internal Medicine and Medical Specialties, AOU Policlinico Umberto I, 00185 Rome, Italy.

Fabrizio ContiRheumatology Unit, Department of Clinical Internal, Anaesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Francesca Romana SpinelliRheumatology Unit, Department of Clinical Internal, Anaesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1969-2097

Clara CrescioliDepartment of Movement, Human and Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy.ORCID 0000-0003-3339-3114

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chemokine CXCL10 contributes to early autoimmune rheumatic disease (ARD) development. Preclinical ARD stages exhibit dendritic cells (DCs), CD4

Indexed as

Autoimmune DiseasesChemokine CXCL10Dendritic CellsMonocytesPPAR-betaPPAR deltaCD4-Positive T-LymphocytesCells, CulturedHumansInterferon-gammaInterleukin-10PPAR-gamma AgonistsRosiglitazoneTumor Necrosis Factor-alphaChemokine CXCL10CXCL10 protein, humanInterferon-gammaInterleukin-10PPAR-betaPPAR deltaPPAR-gamma AgonistsRosiglitazoneTumor Necrosis Factor-alphaARDCXCL10human immunocytesPPARβ/δ

Identifiers

PMID42793157

DOI10.3390/biom16091325

PMCPMC13604882

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.