Evidence map›Paper›PMID 42793154›Full record

ArticleBiomolecules2026

Role of Nuclear SUMO-Targeted Ubiquitin Ligase Uls2 (Slx5-Slx8) in Quality Control of Cytosolic Proteins.

Friederike Profe-Austermann, Lennard-Maximilian Döring, Luisa Schmidt, Lena Avci, Maximilian Haka, Ganapathi Kandasamy, Judith Müller, Nils Johnsson, Marcus Krüger, R Jürgen Dohmen

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Friederike Profe-AustermannCenter of Molecular Biosciences, Institute for Genetics, Department of Biology, Faculty of Natural Sciences and Mathematics, University of Cologne, 50674 Cologne, Germany.ORCID 0009-0005-4202-5921
Lennard-Maximilian DöringCenter of Molecular Biosciences, Institute for Genetics, Department of Biology, Faculty of Natural Sciences and Mathematics, University of Cologne, 50674 Cologne, Germany.
Luisa SchmidtInstitute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50674 Cologne, Germany.ORCID 0000-0002-9805-4941
Lena AvciCenter of Molecular Biosciences, Institute for Genetics, Department of Biology, Faculty of Natural Sciences and Mathematics, University of Cologne, 50674 Cologne, Germany.
Maximilian HakaCenter of Molecular Biosciences, Institute for Genetics, Department of Biology, Faculty of Natural Sciences and Mathematics, University of Cologne, 50674 Cologne, Germany.ORCID 0009-0002-9176-3830
Ganapathi KandasamyCenter of Molecular Biosciences, Institute for Genetics, Department of Biology, Faculty of Natural Sciences and Mathematics, University of Cologne, 50674 Cologne, Germany.
Judith MüllerDepartment of Biology, Institute of Molecular Genetics and Cell Biology, Ulm University, 89081 Ulm, Germany.
Nils JohnssonDepartment of Biology, Institute of Molecular Genetics and Cell Biology, Ulm University, 89081 Ulm, Germany.ORCID 0000-0003-1416-835X
Marcus KrügerInstitute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50674 Cologne, Germany.ORCID 0000-0002-5846-6941
R Jürgen DohmenCenter of Molecular Biosciences, Institute for Genetics, Department of Biology, Faculty of Natural Sciences and Mathematics, University of Cologne, 50674 Cologne, Germany.ORCID 0000-0002-5756-6780

Funding

Deutsche Forschungsgemeinschaft Jo 187/8-1Deutsche Forschungsgemeinschaft RTG2550, 411422114
6 · The paper itself

Abstract

The interplay between the posttranslational modifiers SUMO and ubiquitin mediates the degradation of proteins. This crosstalk is conveyed by SUMO-targeted ubiquitin ligases (STUbLs). The best-studied STUbL in

Indexed as

CytosolSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsUbiquitin-Protein LigasesCell NucleusNuclear ProteinsOxidative StressSumoylationNuclear ProteinsSaccharomyces cerevisiae ProteinsSlx5 protein, S cerevisiaeSlx8 protein, S cerevisiaeUbiquitin-Protein LigasesFir1Nis1quality controlSlx5Slx8STUbLSUMO

Identifiers

PMID42793154
PMCPMC13604690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.