Evidence map›Paper›PMID 42793116›Full record

ArticleBiomolecules2026

β3-Adrenergic Signaling Preserves Postnatal Maturation of the Enteric Nervous System and Gut Microbiome During Neonatal Hyperoxia.

Patrizia Nardini, Sara Bertorello, Luca Filippi, Virginia Zizi, Ida Cioffi, Francesco Cei, Simone Baldi, Daniele Bani, Maura Calvani, Camilla Fazi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Patrizia NardiniDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0003-2374-5147
Sara BertorelloDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0009-0005-2267-7551
Luca FilippiNeonatal Intensive Care Unit, Emergency Department, University Children's Hospital Meyer IRCCS, 50134 Florence, Italy.ORCID 0000-0001-5310-9147
Virginia ZiziDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0003-1074-1681
Ida CioffiDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Francesco CeiDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Simone BaldiDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0002-5151-2618
Daniele BaniDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0001-6302-901X
Maura CalvaniDepartment of Oncoematology, University Children's Hospital Meyer IRCCS, 50134 Florence, Italy.ORCID 0000-0003-0750-4706
Camilla FaziDepartment of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy.ORCID 0000-0003-3419-4600
Amedeo AmedeiDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0002-6797-9343
Alessandro PiniDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0001-9828-2082

Funding

Intesa Sanpaolo Charity B/2022/0198).Meyer Foundation Italy 0106182Ministry of Universities and Research OBERON, 2022FYBMEX
6 · The paper itself

Abstract

Oxygen availability is a key regulator of organ maturation during the perinatal period. Disruption of physiological oxygen homeostasis contributes to prematurity-associated disorders, yet its effects on the coordinated maturation of the enteric nervous system (ENS) and gut microbiome remain poorly understood. Because β3-adrenergic receptor (β3-AR) signaling has emerged as a mediator of tissue adaptation to oxygen, we investigated whether activation of this pathway modulates hyperoxia-induced alterations in the developing colon. Newborn rats were exposed to normoxia or hyperoxia (85% O

Indexed as

Enteric Nervous SystemGastrointestinal MicrobiomeHyperoxiaReceptors, Adrenergic, beta-3AnimalsAnimals, NewbornColonFemaleMaleNeurogliaNeuronsRatsRats, Sprague-DawleySignal TransductionReceptors, Adrenergic, beta-3colonenteric nervous systemhyperoxiamicrobiomeprematurityβ3-adrenergic receptor

Identifiers

PMID42793116
PMCPMC13604227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.