Evidence map›Paper›PMID 42793114›Full record

ArticleBiomolecules2026

Thymoquinone Is Effective in Painful Paclitaxel-Induced Peripheral Neuropathy Without Compromising Anticancer Activity.

Ibtihal Segmani, Chiara D'Aprile, Laura Cherchi, Eleonora Pozzi, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Cristina Meregalli, Lisa Fantoni, Elisa Ballarini and 7 more

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ibtihal SegmaniLaboratory of Integrated Cancer Research, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 21100, Morocco.
Chiara D'AprileExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0002-3380-043X
Laura CherchiExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0009-0007-1050-9299
Eleonora PozziExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0001-6438-286X
Alessia ChiorazziExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0002-3469-1829
Annalisa CantaExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0003-4946-647X
Paola AlbertiExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0001-6106-6183
Cristina MeregalliExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0002-4281-4577
Lisa FantoniExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.
Elisa BallariniExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0002-1678-6357
Virginia Rodriguez MenendezExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.
Elisabetta DonzelliExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0002-9495-4256
Silvia FermiExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0009-0007-2387-1035
Arianna ScuteriExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0003-0240-313X
Houda FilaliLaboratory of Integrated Cancer Research, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 21100, Morocco.
Guido CavalettiExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0003-4128-2406
Valentina Alda CarozziExperimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monz, Italy.ORCID 0000-0003-0963-7107

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a dose-limiting complication of paclitaxel (PTX) therapy, for which effective treatments are still lacking. This study evaluated the neuroprotective potential of Thymoquinone (TQ), a bioactive derivative of

Indexed as

BenzoquinonesNeuroprotective AgentsPaclitaxelPainPeripheral Nervous System DiseasesAnimalsAntineoplastic Agents, PhytogenicFemaleGanglia, SpinalHumansMCF-7 CellsMDA-MB-231 CellsRatsRats, Sprague-DawleySirtuin 1Antineoplastic Agents, PhytogenicBenzoquinonesNeuroprotective AgentsPaclitaxelSirtuin 1thymoquinonein vivo/in vitro modelspaclitaxelperipheral neuropathySIRT1 expressionThymoquinone

Identifiers

PMID42793114
PMCPMC13604513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.