Evidence map›Paper›PMID 42793093›Full record

ArticleBiomolecules2026

Ye Wang, Shiyun Sun, Yuhan Zhang, Guoqing Li, Yunlong Xu, Yingxue Shi, Pedro A Jose, Zhiwei Yang, Xing Liu, Xiaoliang Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ye WangInstitute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC), National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Comparative Medicine, National Center of Technology Innovation for Animal Model; State Key Laboratory of Respiratory Health and Multimorbidity, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China.
Shiyun SunInstitute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC), National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Comparative Medicine, National Center of Technology Innovation for Animal Model; State Key Laboratory of Respiratory Health and Multimorbidity, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China.
Yuhan ZhangInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
Guoqing LiInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
Yunlong XuInstitute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC), National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Comparative Medicine, National Center of Technology Innovation for Animal Model; State Key Laboratory of Respiratory Health and Multimorbidity, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China.
Yingxue ShiInstitute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC), National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Comparative Medicine, National Center of Technology Innovation for Animal Model; State Key Laboratory of Respiratory Health and Multimorbidity, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China.
Pedro A JoseDepartment of Pharmacology and Physiology, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.
Zhiwei YangInstitute of Clinical Medical Sciences, China-Japan Friendship Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
Xing LiuInstitute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC), National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Comparative Medicine, National Center of Technology Innovation for Animal Model; State Key Laboratory of Respiratory Health and Multimorbidity, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China.
Xiaoliang JiangInstitute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC), National Human Diseases Animal Model Resource Center, NHC Key Laboratory of Comparative Medicine, National Center of Technology Innovation for Animal Model; State Key Laboratory of Respiratory Health and Multimorbidity, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China.

Funding

D2 receptor variation and renal dysfunctionR01DK134574 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI Pedro A. Jose · 2023 to 2026
$2.8M
Beijing High-level innovation and Entrepreneurship Talent Support Program.ChunLei G202532200National Natural Science Foundation of China 2022YFF0710600National Natural Science Foundation of China 82270289National Natural Science Foundation of China 82270463NIDDK NIH HHS R01 DK134574Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2023-PT180-01Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technol-ogy Major Project 2025ZD01900700the National Institutes of Health 5R01DK134574
6 · The paper itself

Abstract

Hypertension is an important risk factor for cardiovascular and renal diseases, yet the mechanisms linking ion channel dysfunction to hypertension remain poorly understood. The voltage-gated potassium channel Kv1.3 (encoded by

Indexed as

CalciumCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinHypertensionKv1.3 Potassium ChannelProto-Oncogene Proteins c-aktReninAnimalsMiceMice, KnockoutRenin-Angiotensin SystemSignal TransductionCalciumCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinKv1.3 Potassium ChannelProto-Oncogene Proteins c-aktRenincalcium signalingCREBhypertensionKcna3PI3K–AKT pathwayRAASrenin

Identifiers

PMID42793093
PMCPMC13604294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.