Evidence map›Paper›PMID 42793072›Full record

ArticleBiomolecules2026

Optogenetic Evidence for the Intrinsic Phase Separation Propensity of the Sgs1 N-Terminal Region: Implications for Assemblysome Formation.

Bence György Gombás, Erika Gábor, Viktor Honti, Orsolya Németh-Szatmári, Ferenc Jankovics, Zoltán Villányi

Abstract read
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In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bence György GombásDepartment of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary.
Erika GáborDrosophila Blood Cell Differentiation Group, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.ORCID 0000-0002-0477-6127
Viktor HontiDrosophila Blood Cell Differentiation Group, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.
Orsolya Németh-SzatmáriDepartment of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary.
Ferenc JankovicsLaboratory of Drosophila Germ Cell Differentiation, Institute of Genetics, HUN-REN Biological Research Centre, 6726 Szeged, Hungary.ORCID 0000-0001-9697-4472
Zoltán VillányiDepartment of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary.ORCID 0000-0002-8563-9713

Funding

National Research, Development and Innovation Office NKFI-K 142961University of Szeged 8804
6 · The paper itself

Abstract

Assemblysomes are ribosome-nascent chain condensates that regulate co-translational processes through liquid-liquid phase separation, yet the sequence determinants underlying their formation remain incompletely understood. Previous studies identified the DNA helicase Sgs1 as an assemblysome-associated protein; however, whether its N-terminal region possesses intrinsic phase separation propensity has not been experimentally examined. Here, we investigated the first 135 amino acids of Sgs1 using a light-inducible optoDroplet assay. A mCherry-Cry2-Sgs1

Indexed as

OptogeneticsRecQ HelicasesBiomolecular CondensatesHEK293 CellsHumansPhase SeparationRecQ Helicasesassemblysomebiomolecular condensatesliquid–liquid phase separationoptoDropletribosome-nascent chain complexSgs1

Identifiers

PMID42793072
PMCPMC13604679

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.