Evidence map›Paper›PMID 42793044›Full record

ReviewGenes2026

Decoding MAPT Exon 10 Mis-Splicing in FTDP-17: From Pathogenic Mechanisms and Experimental Models to Molecular Therapies.

Giuseppina Covello

Abstract readReview
In one paragraph

Review in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Giuseppina CovelloDepartment of Biology, University of Padua, 35131 Padua, Italy.ORCID 0000-0001-5660-8283

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frontotemporal Dementia and Parkinsonism linked to chromosome 17 (FTDP-17) is a rare, early-onset, autosomal-dominant neurodegenerative tauopathy caused by mutations in the

Indexed as

Alternative SplicingExonsFrontotemporal Dementiatau ProteinsAnimalsHumansMutationOligonucleotides, AntisenseMAPT protein, humanOligonucleotides, Antisensetau Proteinsalternative splicingantisense oligonucleotides (ASOs)cerebral organoidsFTDP-17human iPSC modelsintrathecal drug deliveryMAPT exon 10RNA interference (siRNA)small-molecule splicing modulatorstau 3R/4R ratio

Identifiers

PMID42793044
PMCPMC13606898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.