Single-Cell Transcriptomic Profiling of Peripheral Blood in a Patient with Progressive Thyroid Eye Disease Following Total Thyroidectomy.

Ainura Mussakulova, Zarina Zhalgasbaeva, Vyacheslav Korobeynikov, Gulnur Zhunussova

Abstract readCase Reports

In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Ainura MussakulovaLaboratory of Molecular Genetics, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan.

Zarina ZhalgasbaevaLaboratory of Molecular Genetics, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan.

Vyacheslav KorobeynikovCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 634009, Russia.

Gulnur ZhunussovaLaboratory of Molecular Genetics, Institute of Genetics and Physiology, Almaty 050060, Kazakhstan.ORCID 0000-0001-8642-9577

Funding

Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan AP25795047

6 · The paper itself

Abstract

Thyroid eye disease (TED) is an autoimmune inflammatory disorder of the orbit closely associated with thyroid dysfunction. Total thyroidectomy is traditionally expected to attenuate the autoimmune cascade, yet some patients continue to progress after surgery, which challenges this paradigm and points to a potentially autonomous orbital immune response. To investigate this, we performed single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) from a 47-year-old woman with severe, glucocorticoid-refractory TED, four years after total thyroidectomy, and compared her immune landscape with that of an age- and sex-matched healthy control. The patient's peripheral blood showed a clear shift toward an active, stress-associated inflammatory state: pro-inflammatory mediators, immediate-early response transcription factors (

Indexed as

Graves OphthalmopathyThyroidectomyTranscriptomeFemaleGene Expression ProfilingHumansLeukocytes, MononuclearMiddle AgedSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisCXCR4Graves’ orbitopathyimmunometabolismperipheral blood mononuclear cellssingle-cell RNA sequencingthyroid eye diseasetotal thyroidectomy

Identifiers

PMID42793037

DOI10.3390/genes17091143

PMCPMC13606414

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.