Evidence map›Paper›PMID 42792984›Full record

ArticleGenes2026

The Association Between Hyperketonemia and Reduced Circulating Hydrogen Sulfide in Children with Type 1 Diabetes, and Ketone Inhibition of Cystathionine-γ-Lyase mRNA Expression in Cultured Hepatocytes.

Sushil K Jain, Rajesh Parsanathan, Jeffrey Justin Margret, Neslihan Gungor, John A Vanchiere, Maroun J Mhanna, Robert McVie

Abstract read
In one paragraph

Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sushil K JainDepartment of Pediatrics, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.ORCID 0000-0002-9574-0436
Rajesh ParsanathanDepartment of Pediatrics, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.ORCID 0000-0001-8973-3507
Jeffrey Justin MargretDepartment of Pediatrics, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.ORCID 0000-0001-7905-1887
Neslihan GungorDepartment of Pediatrics, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.
John A VanchiereDepartment of Pediatrics, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.
Maroun J MhannaDepartment of Pediatrics, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.ORCID 0000-0002-9184-9389
Robert McVieDepartment of Pediatrics, Louisiana State University Health Shreveport, Shreveport, LA 71103, USA.

Funding

Optimization of Glutathione Levels and Alzheimer Disease Risk in African AmericansR33AT010637 · NCCIH · LOUISIANA STATE UNIV HSC SHREVEPORT · PI JAIN, SUSHIL K · 2020 to 2022
$1.9M
Malcolm Feist Endowed Chair in DiabetesNCCIH NIH HHS R33 AT010637NIH HHS 3R33AT010637-02S1NIH HHS 5R33AT010637-01A1
6 · The paper itself

Abstract

backgroundHydrogen sulfide (H

objectiveThis study aims to test the hypothesis that ketones decrease

methodsFasting blood samples were collected from children with T1D (

resultsBlood levels of H

conclusionsLower circulating H

Indexed as

Cystathionine gamma-LyaseDiabetes Mellitus, Type 1HepatocytesHydrogen SulfideKetonesKetosisAcetoacetatesAdolescentCells, CulturedChildFemaleHumansHyperglycemiaMaleRNA, MessengerAcetoacetatesacetoacetic acidCystathionine gamma-LyaseHydrogen SulfideKetonesRNA, MessengerCSEgene expressionHDL-cholesterolhepatocyteshydrogen sulfidehyperglycemiahyperketonemiaketonetype 1 diabetesvitamin D

Identifiers

PMID42792984
PMCPMC13606490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.