ArticleGenes2026
Genetic Susceptibility to Impaired Lung Function in Underground Coal Miners from Kazakhstan.
Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
BACKGROUND/
objectivesOccupational exposure to coal mine dust is a major risk factor for respiratory impairment; however, the genetic determinants of individual variation in lung function remain poorly understood, particularly in occupational cohorts that have been largely absent from genome-wide association studies. This study aimed to identify genetic variants associated with quantitative lung function traits in underground coal miners from Kazakhstan.
methodsA total of 186 underground coal miners from the Karaganda coal basin were genotyped using the Illumina Global Screening Array. Genome-wide association analyses were performed for six spirometric parameters (FVC, FEV1, FEV1/FVC, MEF25, MEF50, and MEF75), adjusting for age, mining exposure, body mass index, smoking status, and population structure. Genotype imputation was performed to increase genomic coverage and evaluate the consistency of association signals.
resultsNo variants reached the conventional genome-wide significance threshold. However, recurrent suggestive associations identified
conclusionsRecurrent associations across complementary spirometric parameters identified biologically plausible candidate loci involved in inflammatory signalling, DNA repair, and epithelial homeostasis. These findings provide one of the first genomic insights into lung function in underground coal miners and provide a foundation for future validation and functional studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.