Evidence map›Paper›PMID 42792853›Full record

ArticleBiomedicines2026

Evaluation of Spontaneous Pain in a Monosodium Iodoacetate-Induced Mouse Model of Osteoarthritis Using the Mouse Grimace Scale.

Mohammed Alnoud, Jose Rios, Megan W Szobody, Ayesha A Usman, Alma Rodriguez, Thao-April Nguyen, Seryna Ayala, Ayaan S Quraishi, Massimo Salinas, Khalid Benamar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammed AlnoudDepartment of Neuro-Behavioral Health, Institute of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Jose RiosDepartment of Neuro-Behavioral Health, Institute of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.ORCID 0009-0005-4392-2923
Megan W SzobodyDepartment of Neuro-Behavioral Health, Institute of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Ayesha A UsmanDepartment of Neuro-Behavioral Health, Institute of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.ORCID 0009-0004-5250-4101
Alma RodriguezDepartment of Neuro-Behavioral Health, Institute of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Thao-April NguyenDepartment of Neuro-Behavioral Health, Institute of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Seryna AyalaDepartment of Neuro-Behavioral Health, Institute of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Ayaan S QuraishiDepartment of Neuro-Behavioral Health, Institute of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Massimo SalinasDepartment of Neuro-Behavioral Health, Institute of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Khalid BenamarDepartment of Neuro-Behavioral Health, Institute of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.ORCID 0009-0000-5590-8321

Funding

NINDS NIH HHS NS134408
6 · The paper itself

Abstract

Animal models are critical for elucidating disease mechanisms and pathological outcomes, and for evaluating therapeutic interventions. Osteoarthritis (OA) is a leading cause of chronic pain and disability globally. Clinically, individuals with OA experience both sensory and ongoing pain. However, ongoing pain, as assessed by the Mouse Grimace Scale (MGS), has not yet been evaluated in animal models of OA. This study aims to address this significant knowledge gap. We induced OA by intra-articular injection of monosodium iodoacetate (MIA), while control mice received saline injections. We assessed pain behaviors using the MGS on days 1, 3, 7, and 14 after MIA administration. MIA-treated mice exhibited significantly higher MGS scores than saline-treated controls throughout the study period, indicating ongoing pain-related behavior in the MIA OA model. Furthermore, longitudinal studies showed that this pain is chronic, as seen in people with OA. These findings support the usefulness of the MGS test in the MIA model for studying ongoing pain.

Indexed as

monosodium iodoacetateMouse Grimace Scaleongoing painOsteoarthritispain

Identifiers

PMID42792853
PMCPMC13604891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.