ReviewBiomedicines2026
Skin Resilience and Biological Adaptability: Current Clinical Evidence on Micronutrients and Bioactive Compounds.
Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin resilience and biological adaptability describe the capacity of cutaneous tissue to preserve structural integrity and functional stability under intrinsic aging and environmental stress. Rather than introducing a novel biological pathway, this framework integrates established domains, including redox homeostasis, extracellular matrix maintenance, inflammatory regulation, and barrier function, into a measurable construct. Micronutrients and bioactive compounds participate in these processes; however, the strength and clinical relevance of current evidence require critical evaluation. This structured narrative review appraises mechanistic and clinical studies published between 2000 and 2025 investigating nutritional modulation of measurable skin parameters. Electronic database searches (PubMed/MEDLINE, Scopus, Web of Science) were conducted using predefined terms related to skin aging, resilience-related endpoints, and micronutrient interventions. Controlled human trials were prioritized, and mechanistic findings were distinguished from clinical outcomes. Current clinical evidence most consistently supports a role for carotenoids and antioxidant vitamins in enhancing cutaneous redox stability and short-term photoprotection. Collagen-based formulations and selected polyphenols demonstrate modest improvements in elasticity, hydration, and wrinkle-related parameters, though many trials are limited by small sample sizes, short duration, and heterogeneous endpoints. Overall, micronutrients appear to function primarily as modulators of adaptive capacity rather than as primary drivers of structural rejuvenation. Larger, longer-term randomized trials employing standardized resilience-related endpoints are needed to clarify the magnitude and durability of clinically meaningful effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.