Evidence map›Paper›PMID 42792641›Full record

ArticleBiomedicines2026

Rewiring of Molecular Networks Induced by the Combination of Loratadine, Raloxifene, and Sorafenib Leads to the Identification of Clinically Relevant Therapeutic Targets in Hepatocellular Carcinoma.

Fernanda Villarruel-Melquiades, Nancy Santos-Martínez, Martha Noyola-Díaz, Estefanía de Jesús Terán-Sánchez, José Iván Serrano-Contreras, Luis Gerardo Zepeda-Vallejo, María Eugenia Mendoza-Garrido, Julio Isael Pérez-Carreón, Cecilia Bañuelos, Georgina Hernández-Montes and 1 more

Abstract read
In one paragraph

Article in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fernanda Villarruel-MelquiadesDepartamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Ciudad de Mexico CP 07360, Mexico.ORCID 0000-0001-8156-0090
Nancy Santos-MartínezIndependent Researcher, CP 33000 Bordeaux, France.ORCID 0000-0003-4542-7035
Martha Noyola-DíazDepartamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Ciudad de Mexico CP 07360, Mexico.
Estefanía de Jesús Terán-SánchezDepartamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, Col. Santo Tomas, Alcaldía Miguel Hidalgo, Ciudad de Mexico CP 11340, Mexico.ORCID 0009-0003-1335-5257
José Iván Serrano-ContrerasDepartment of Metabolism, Digestion and Reproduction, Section of Nutrition, Faculty of Medicine, Commonwealth Building Hammersmith Campus, Imperial College London, London W12 0NN, UK.ORCID 0000-0001-8669-7571
Luis Gerardo Zepeda-VallejoDepartamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, Col. Santo Tomas, Alcaldía Miguel Hidalgo, Ciudad de Mexico CP 11340, Mexico.ORCID 0000-0001-6637-8565
María Eugenia Mendoza-GarridoDepartamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Ciudad de Mexico CP 07360, Mexico.ORCID 0000-0003-2037-0618
Julio Isael Pérez-CarreónInstituto Nacional de Medicina Genómica (INMEGEN), Periférico Sur No. 4809, Col. Arenal Tepepan, Ciudad de Mexico CP 14610, Mexico.ORCID 0000-0001-9284-7775
Cecilia BañuelosPrograma Transdisciplinario en Desarrollo Científico y Tecnológico para la Sociedad, Departamento de Investigación y Estudios Multidisciplinarios, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Ciudad de Mexico CP 07360, Mexico.ORCID 0000-0002-8168-4488
Georgina Hernández-MontesRed de Apoyo a la Investigación, Coordinación de Investigación Científica, Universidad Nacional Autónoma de Mexico, Ciudad de Mexico CP 14080, Mexico.
Javier CamachoDepartamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, Ciudad de Mexico CP 07360, Mexico.ORCID 0000-0002-8886-086X

Funding

Secretaría de Ciencia, Humanidades, Tecnología e Innovación CF-2023-I-812
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

drug combinationdrug repurposinghepatocellular carcinomaloratadinemulti-omicsraloxifenesorafenib

Identifiers

PMID42792641
PMCPMC13604568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.