ArticleBiology2026
Beyond Mean HU: Spatial Radiodensity Mapping of the Human Hyoid as a Baseline for Morphological and Biomechanical Investigation.
Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Bone radiodensity is often reduced to global Hounsfield Unit (HU) summaries, although its spatial distribution may contain biologically relevant information. This study introduced a template-based framework for spatial radiodensity mapping of the adult human hyoid and tested whether spatial descriptors capture age- and sex-related variation better than whole-bone HU measures. Clinical head-and-neck CT scans from 300 adults, including 180 females and 120 males, were analyzed. Hyoids were segmented, normalized into a common anatomical template, and divided into 1500 supervoxels for spatial analysis. Scalar HU summaries were compared with PCA-based spatial descriptors, and regional effects were assessed using supervoxel-wise models with false-discovery-rate correction. The registered radiodensity maps showed spatial coherence, with neighboring supervoxels displaying more similar profiles than distant ones. In this cohort, spatial descriptors outperformed mean HU for age prediction, although performance remained limited (R
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