Evidence map›Paper›PMID 42792438›Full record

ArticleBehavioral sciences (Basel, Switzerland)2026

Miriam Pavelth Casillas-Ávila, Christian Gabriel Toledo-Lozano, Luis Ángel Montes Almanza, Ramón Mauricio Coral-Vázquez, Isabel Ramírez Sixtos, Omar Medrano Espinosa, Silvia García, Cristina Rodríguez Hernández, Froylan Arturo García Martínez, Edgar Oswaldo Zamora González and 7 more

Abstract read
In one paragraph

Article in Behavioral sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Miriam Pavelth Casillas-ÁvilaPrograma de Doctorado en Genética Humana, Universidad de Guadalajara, Guadalajara 44100, Mexico.
Christian Gabriel Toledo-LozanoSubdirección de Enseñanza e Investigación, Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City 03100, Mexico.ORCID 0000-0001-7418-1228
Luis Ángel Montes AlmanzaPrograma de Maestría en Ciencias de la Salud, Instituto Politécnico Nacional, Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City 03100, Mexico.ORCID 0000-0002-6601-3686
Ramón Mauricio Coral-VázquezSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.ORCID 0000-0001-6126-2002
Isabel Ramírez SixtosPrograma de Maestría en Ciencias de la Salud, Instituto Politécnico Nacional, Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City 03100, Mexico.
Omar Medrano EspinosaPrograma de Maestría en Ciencias de la Salud, Instituto Politécnico Nacional, Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City 03100, Mexico.ORCID 0009-0008-5110-0614
Silvia GarcíaSubdirección de Enseñanza e Investigación, Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City 03100, Mexico.ORCID 0000-0003-1760-3150
Cristina Rodríguez HernándezPrograma de Maestría en Ciencias de la Salud, Instituto Politécnico Nacional, Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City 03100, Mexico.
Froylan Arturo García MartínezPrograma de Maestría en Ciencias de la Salud, Instituto Politécnico Nacional, Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City 03100, Mexico.
Edgar Oswaldo Zamora GonzálezCentro Universitario del Norte (CUNORTE), Universidad de Guadalajara, Colotlán 46200, Mexico.ORCID 0000-0003-3780-5374
Guillermo García CastilloSubdirección de Enseñanza e Investigación, Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City 03100, Mexico.
Benjamín Gómez DíazInstituto Nacional de Rehabilitación, Mexico City 14389, Mexico.
Matxil Violeta Díaz BenavidesDepartamento Ciclo de Vida, Universidad Autónoma de Guadalajara, Zapopan 45134, Mexico.
Stephanie Alejandra Rosas-MaldonadoDepartamento Ciclo de Vida, Universidad Autónoma de Guadalajara, Zapopan 45134, Mexico.
Cristina Gutiérrez MendozaInstituto Nacional de Rehabilitación, Mexico City 14389, Mexico.
Carlos Palma FloresInvestigadores por México, Secretaría de Ciencia, Humanidades, Tecnología e Innovación (SECIHTI), Mexico City 03940, Mexico.
Luz Berenice López-HernándezDepartamento Ciclo de Vida, Universidad Autónoma de Guadalajara, Zapopan 45134, Mexico.ORCID 0000-0003-3912-6754

Funding

Institute for Social Security and Services for State Workers E015 382.2014Universidad Autónoma de Guadalajara Fondo semilla
6 · The paper itself

Abstract

backgroundMajor depressive disorder (MDD) arises from genetic and environmental factors. We evaluated functional variation in methylenetetrahydrofolate reductase (

methodsWe analyzed 1507 individuals across four cohorts: a primary case-control sample (358 DSM-IV-TR MDD cases, 170 psychiatrically screened controls), a community cohort (

resultsThe rs13306560 A allele was rare (~2.6%) and showed no association with MDD. Under a recessive model, the rs1801133 TT genotype was more frequent among cases (33.3%) than controls (23.5%) (χ

conclusionsIn this Mexican-Mestizo sample,

Indexed as

depressionfolatefunctional SNPMexican-MestizosMTHFR

Identifiers

PMID42792438
PMCPMC13603558

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.