Bioactive Compound Recovery from Apple Pomace by Aqueous Ultrasound-Assisted Extraction: Machine Learning Modelling and Multi-Objective Optimization.

Biljana Lončar, Milena Terzić, Aleksandra Cvetanović Kljakić, Mirjana Petronijević, Sanja Panić, Jelena Arsenijević, Gokhan Zengin, Slavica Ražić

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Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Biljana LončarFaculty of Technology Novi Sad, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia.ORCID 0000-0003-2994-6871

Milena TerzićFaculty of Technology Novi Sad, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia.ORCID 0000-0001-7192-4962

Aleksandra Cvetanović KljakićFaculty of Technology Novi Sad, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia.ORCID 0000-0001-5621-1788

Mirjana PetronijevićFaculty of Technology Novi Sad, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia.

Sanja PanićFaculty of Technology Novi Sad, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia.ORCID 0000-0001-8438-634X

Jelena ArsenijevićFaculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia.ORCID 0000-0001-6080-0526

Gokhan ZenginScience Faculty, Selcuk University, Campus Konya, Konya 42130, Turkey.ORCID 0000-0001-6548-7823

Slavica RažićFaculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia.ORCID 0000-0002-4884-040X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apple pomace represents a sustainable source of phenolic compounds with significant antioxidant potential. This study investigated the recovery of water-extractable bioactive constituents from apple pomace using aqueous ultrasound-assisted extraction (UAE) combined with biochemical profiling and machine learning-based modelling. Extraction conditions were varied according to time (10-30 min), temperature (25-75 °C), and solvent-to-solid ratio (10-20 mL/g). The obtained extracts were evaluated for total phenolic content (TP), total flavonoid content (TF), antioxidant capacity (DPPH, ABTS, CUPRAC, FRAP, metal chelating, and phosphomolybdenum assays), and enzyme inhibitory activities against acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-amylase, and α-glucosidase. TP and TF ranged from 4.70 to 9.97 mg GAE/g and 0.21-0.79 mg RE/g, respectively, while antioxidant assays demonstrated substantial variation depending on extraction conditions. Strong correlations (r = 0.827-0.945,

Indexed as

antioxidant activityapple pomaceaqueous ultrasound-assisted extractionenzyme inhibitionmachine learningphenolic compoundsprocess optimizationsustainable valorisation

Identifiers

PMID42792255

DOI10.3390/antiox15091215

PMCPMC13603890

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