Evidence map›Paper›PMID 42792156›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Carnosine Potentiates a Compensatory Mitochondrial-Synaptic Proteomic Response in the ALS Cerebellum.

Hellen P Valerio, Valeria Oliveira, Stephanie Y Ferreira, Isabel R Pereira, Giuseppe Palmisano, Mariana P Massafera, Vanderson S Bispo, Fernanda M Prado, Paolo Di Mascio, Marisa H G Medeiros

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hellen P ValerioGlycoProteomics Laboratory, Department of Parasitology, ICB, Universidade de São Paulo, São Paulo 05508-000, Brazil.
Valeria OliveiraDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-0149-9707
Stephanie Y FerreiraDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, Brazil.ORCID 0009-0001-6921-2285
Isabel R PereiraDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, Brazil.ORCID 0009-0005-5921-0824
Giuseppe PalmisanoGlycoProteomics Laboratory, Department of Parasitology, ICB, Universidade de São Paulo, São Paulo 05508-000, Brazil.
Mariana P MassaferaDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, Brazil.
Vanderson S BispoDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, Brazil.
Fernanda M PradoDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-4458-4354
Paolo Di MascioDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-4125-8350
Marisa H G MedeirosDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-5438-1174

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304350/2023-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 304945/2021-8Conselho Nacional de Desenvolvimento Científico e Tecnológico 408213/2024-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/07937-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/11334-6
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron degeneration and chronic neuroinflammation in the brain and spinal cord, involving complex interactions between neurons and immune cells. Carnosine (β-alanyl-L-histidine) has pathophysiological relevance due to its ability to detoxify reactive carbonyl species, including α,β-unsaturated aldehydes, scavenge free radicals, and chelate zinc, and has also been proposed to function in the central nervous system as a histidine reservoir for histamine synthesis. Here, we investigated the effects of carnosine supplementation on the cerebellar proteome of SOD1

Indexed as

amyotrophic lateral sclerosiscarnosinecerebellumproteomicsSOD1G93A

Identifiers

PMID42792156
PMCPMC13603265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.