Evidence map›Paper›PMID 42792117›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Cord Blood Adductomic Profiling Provides Preliminary Insights on Perinatal Smoking Exposure: A Pilot Analysis.

Janu Newar, Elizabeth Brees, Erika T Lin, Abhik Chakraborty, Aliyah Abanes, Kathleen M Fisch, William Funk, Karen K Mestan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Janu NewarDepartment of Pediatrics, Division of Neonatology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0002-3772-1501
Elizabeth BreesDepartment of Pediatrics, Division of Neonatology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Erika T LinDepartment of Pediatrics, Division of Neonatology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0001-9775-0868
Abhik ChakrabortyDepartment of Pediatrics, Division of Neonatology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.ORCID 0000-0002-9067-4900
Aliyah AbanesDepartment of Pediatrics, Division of Neonatology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Kathleen M FischDepartment of Obstetrics/Gynecology and Reproductive Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
William FunkDepartment of Preventive Medicine, Northwestern University, 680 North Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA.
Karen K MestanDepartment of Pediatrics, Division of Neonatology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
TR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6M
The Role of Placental Maternal Vascular Underperfusion in Neonatal Pulmonary HypertensionR01HL139798 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESTAN, KAREN K · 2018 to 2022
$2.5M
Acquisition of a Thermo Fisher Scientific Q Exactive UHMR mass spectrometerS10OD025194 · OD · NORTHWESTERN UNIVERSITY · PI COMPTON, PHILIP DANIEL · 2018 to 2018
$795k
Cord Blood Adductomics in Bronchopulmonary DysplasiaR21HD100831 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESTAN, KAREN K · 2020 to 2021
$458k
NCATS NIH HHS UL1 TR001442NCI NIH HHS P30 CA060553NHLBI NIH HHS R01 HL139798NICHD NIH HHS R21 HD100831NIGMS NIH HHS P41 GM108569NIH HHS 5R01HL139798-04NIH HHS 5R21HD100831-03NIH HHS S10 OD025194
6 · The paper itself

Abstract

Maternal smoking during pregnancy (MSDP) remains a significant public health concern. The molecular mechanisms underlying smoking-induced maternal-fetal impact remain incompletely understood. Newer omics platforms, such as cord blood adductomics, can provide preliminary insight into the "perinatal exposome" leading up to birth. The objective of this study is to explore the adductomic signatures of oxidant stress in cord blood associated with MSDP. In a cohort of mother-infant dyads enrolled at a single birth center in Chicago, IL (2008-2021), we conducted a secondary analysis of self-reported maternal smoking exposure data that was linked to an existent adductomics database of 105 addition products (adducts) measured in cord blood plasma. Principal component analysis (PCA), volcano plots and PERMANOVA were used to visualize the variability in adductomic profiles and to compare significantly increased and decreased adduct concentrations according to self-reported current-smokers, former-smokers, and never-smokers. N = 158 participants (N = 6 current-smokers, 26 former-smokers, and 126 never-smokers) had documented self-reported smoking status and were included in the analysis. PCA demonstrated separation between current-smokers and the other groups (R

Indexed as

maternal smokingneonatal outcomeperinatal oxidant stresspreterm birth

Identifiers

PMID42792117
PMCPMC13603371

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.