ArticleAntioxidants (Basel, Switzerland)2026
Mitochondrial Quality Control Impairment Is a Hallmark of TDP-43
Giuseppe Petito, Maria Ventriglia, Victoria Stefania Del Fiore, Arianna Cuomo, Federica Cioffi, Francesco Manfrevola, Flora Guerra, Lucia Bertuccini, Giulia Ricci, Gilda Cobellis and 4 more
Abstract read
In one paragraphArticle in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Giuseppe PetitoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0009-0006-5470-0354 Maria VentrigliaDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.
Victoria Stefania Del FioreDepartment of Experimental Medicine (DiMeS), University of Salento, Via Provinciale Lecce-Monteroni n.165, 73100 Lecce, Italy.ORCID 0000-0002-6768-5943 Arianna CuomoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.
Federica CioffiDepartment of Sciences and Technologies, University of Sannio, 82100 Benevento, Italy.
Francesco ManfrevolaDepartment of Experimental Medicine, University of Campania "L. Vanvitelli", 80138 Naples, Italy.
Flora GuerraDepartment of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Lecce-Monteroni n.165, 73100 Lecce, Italy.ORCID 0000-0003-3379-7469 Lucia BertucciniCore Facilities Microscopy Area, Italian National Institute of Health, Viale Regina Elena n. 299, 00161 Rome, Italy.ORCID 0000-0002-4278-2376 Giulia RicciDepartment of Experimental Medicine, University of Campania "L. Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-2199-170X Gilda CobellisDepartment of Experimental Medicine, University of Campania "L. Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-5884-9208 Antonia LanniDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0000-0001-5797-0348 Cecilia BucciDepartment of Experimental Medicine (DiMeS), University of Salento, Via Provinciale Lecce-Monteroni n.165, 73100 Lecce, Italy.ORCID 0000-0002-6232-6183 Roberta RomanoDepartment of Experimental Medicine (DiMeS), University of Salento, Via Provinciale Lecce-Monteroni n.165, 73100 Lecce, Italy.ORCID 0000-0002-4987-3561 Rosalba SeneseDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "L. Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.ORCID 0000-0003-1571-0980 Funding
Ministry of Universities and Research Grant No. P2022FBZXY
6 · The paper itselfAbstract
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder strongly associated with mitochondrial dysfunction and impaired proteostasis. Mutations in TARDBP, encoding TAR DNA-binding protein 43 (TDP-43), contribute to disease pathogenesis through cytoplasmic mislocalization and aggregation. Among these, the ALS-linked TDP-43
Indexed as
Amyotrophic Lateral Sclerosis (ALS)Endoplasmic Reticulum stressmitochondrial dysfunctionMitochondrial Quality Control (MQC)mitochondrial Unfolded Protein Response (UPRmt)mitophagyoxidative stressTDP-43
Identifiers
PMID42792090
PMCPMC13603339
What OpenQuestion holds
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