ArticleAntibiotics (Basel, Switzerland)2026
Receptor Structure Shapes Host Range but Incompletely Predicts High Activity in
Article in Antibiotics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRational design of phage cocktails typically relies on the lytic spectrum. However, susceptibility criteria vary widely among studies, ranging from qualitative lysis in spot tests to quantitative endpoints based on serial-dilution titration or efficiency of plating.
methodsWe investigated this discrepancy using four commercial phage cocktails and two capsule-specific monophages against a clinically representative collection of 448
resultsWe identified a systematic discrepancy between these two measures of cocktail efficacy. HR coverage reached 64%, whereas PTA was significantly lower, with a median HR-PTA difference of 36%. This discrepancy persisted for capsule-specific monophages tested against KL2 isolates (
conclusionsCapsule matching can therefore help estimate population-level coverage but does not fully predict high-titre activity. Phage selection should incorporate serial-dilution testing rather than rely on spot-test lysis alone. Cocktail design should account for both receptor coverage and functional activity against representative isolates within individual capsule types.
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