Evidence map›Paper›PMID 42791873›Full record

ArticleBioengineering (Basel, Switzerland)2026

Stable Constitutive BiP Expression Prolongs Late-Stage GLP-1-Fc Accumulation in CHO Cells.

Rolan R Shaifutdinov, Fedor A Krukov, Anastasia S Samok, Ivan I Vorobiev, Nadezhda A Orlova

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rolan R ShaifutdinovLaboratory of Mammalian Cell Bioengineering, Skryabin Institute of Bioengineering, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, 60 let Oktjabrja pr-t 7, bld. 1, 117312 Moscow, Russia.ORCID 0009-0007-5118-5067
Fedor A KrukovLaboratory of Mammalian Cell Bioengineering, Skryabin Institute of Bioengineering, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, 60 let Oktjabrja pr-t 7, bld. 1, 117312 Moscow, Russia.ORCID 0009-0006-9126-4854
Anastasia S SamokLaboratory of Mammalian Cell Bioengineering, Skryabin Institute of Bioengineering, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, 60 let Oktjabrja pr-t 7, bld. 1, 117312 Moscow, Russia.ORCID 0009-0005-3822-221X
Ivan I VorobievLaboratory of Mammalian Cell Bioengineering, Skryabin Institute of Bioengineering, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, 60 let Oktjabrja pr-t 7, bld. 1, 117312 Moscow, Russia.ORCID 0000-0003-0064-4458
Nadezhda A OrlovaLaboratory of Mammalian Cell Bioengineering, Skryabin Institute of Bioengineering, Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, 60 let Oktjabrja pr-t 7, bld. 1, 117312 Moscow, Russia.ORCID 0000-0001-9483-2892

Funding

Russian Science Foundation 25-24-00140
6 · The paper itself

Abstract

Chinese hamster ovary (CHO) cells are the principal platform for manufacturing recombinant biopharmaceuticals, but sustained production can exceed the protein-folding capacity of the endoplasmic reticulum (ER). Binding immunoglobulin protein (BiP/GRP78), encoded by

Indexed as

BiPChinese hamster ovary cellsCHO cell engineeringdulaglutideendoplasmic reticulum stressFc-fusion proteinfed-batch cultureGRP78HSPA5unfolded protein response

Identifiers

PMID42791873
PMCPMC13603897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.