Evidence map›Paper›PMID 42791792›Full record

ArticleAnimals : an open access journal from MDPI2026

Genome-Wide Analysis of DNA Methylation Profiles on Jining Grey Goat Uterus Associated with Prolificacy Using Whole-Genome Bisulfite Sequencing.

Cunming Yang, Junmin He, Jingyi Mao, Xue Li, Guifen Liu, Guoping Zhang, Chen Wei, Yifan Ren, Kechuan Tian, Xixia Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cunming YangShandong Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Husbandry and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.ORCID 0000-0001-8687-7337
Junmin HeCollege of Life Sciences, Xinjiang Normal University, Urumqi 830017, China.ORCID 0000-0003-3573-8198
Jingyi MaoShandong Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Husbandry and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Xue LiCollege of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China.
Guifen LiuShandong Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Husbandry and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Guoping ZhangShandong Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Husbandry and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Chen WeiShandong Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Husbandry and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.ORCID 0000-0002-9580-5068
Yifan RenShandong Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Husbandry and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.ORCID 0009-0006-1888-0220
Kechuan TianShandong Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Husbandry and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China.
Xixia HuangCollege of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China.

Funding

National Natural Science Foundation of China No. 32372851Shandong Academy of Agricultural Sciences CXGC2026G06Shandong Academy of Sciences No. SDCX-ZG-202400120
6 · The paper itself

Abstract

Litter size is a vital economic trait in goat production, and previous studies on its regulatory mechanisms mainly focus on ovarian tissues. The genome-wide DNA methylation landscape of the goat uterus and its association with prolificacy remain poorly understood. In this study, we performed whole-genome bisulfite sequencing (WGBS) on uterine tissues from high-prolificacy (HP) and low-prolificacy (LP) Jining Grey Goats to explore epigenetic regulatory mechanisms underlying litter size. A total of 880 differentially methylated regions (DMRs) and 274 differentially methylated genes (DMGs) were identified. Combined with transcriptome data, 21 genes were found to exhibit both differential methylation and differential expression. Three candidate genes (

Indexed as

differentially methylated genesJining Grey Goatlitter sizeuteruswhole-genome bisulfite sequencing

Identifiers

PMID42791792
PMCPMC13603397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.