Evidence map›Paper›PMID 42791743›Full record

ArticleAnimals : an open access journal from MDPI2026

Effects of SIRT7 Inhibition on Milk Fat Synthesis and Fatty Acid Composition in Dairy Goat Mammary Epithelial Cells.

Jun Li, Zhongying Li, Menghan Han, Mengfan Zhao, Zhuoying Li, Huibin Shi, Haoyuan Han, Kun Liu, Xing Liu, Kai Quan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jun LiCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.ORCID 0000-0002-3758-4084
Zhongying LiCollege of Animal Science and Technology, Ningxia University, Yinchuan 750021, China.
Menghan HanCollege of Animal Science and Technology, Ningxia University, Yinchuan 750021, China.
Mengfan ZhaoCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Zhuoying LiCollege of Animal Science and Technology, Ningxia University, Yinchuan 750021, China.
Huibin ShiCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Haoyuan HanCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Kun LiuCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.ORCID 0009-0006-8053-5591
Xing LiuZhengzhou Agricultural Technology Extension Center, Zhengzhou 450006, China.
Kai QuanCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.ORCID 0000-0002-0015-8663

Funding

The Foundation of Key Technology Research Project of Henan Province 262102110065the Henan Provincial Major Industrial Key Technology Research and Development Project 261000110600The Natural Science Foundation of Henan 242300420148The Program for Innovative Research Team in University of Henan Province 25IRTSTHN027
6 · The paper itself

Abstract

Milk fat, a key nutritional component of milk, not only supplies energy and immune protection for offspring but also serves as a critical quality indicator for goat milk. Sirt7, one of the least studied members of the Sirtuins family, has been shown to play a regulatory role in lipid metabolism. This study investigated the regulatory role of Sirt7 in milk fat synthesis and fatty acid composition in dairy goat mammary epithelial cells (GMECs) using a Sirt7 inhibitor (ID: 97491). GMECs were treated with a Sirt7 inhibitor (ID: 97491), and cell viability was assessed via the CCK-8 assay, which confirmed that 15 μmol/L inhibitor had no cytotoxic effects. Functional analyses using RT-qPCR, Western blot, and GC-MS revealed that Sirt7 inhibition upregulated the expression of

Indexed as

dairy goatfatty acid compositioninhibitor (ID: 97491)milk fat synthesisSirt7

Identifiers

PMID42791743
PMCPMC13603759

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.