Patient-Specific Computational Fluid Dynamics of Pulmonary Arterial Hemodynamics in Dogs with and Without Pulmonic Stenosis.

Pulmonic stenosis (PS) is one of the most common congenital cardiac diseases in dogs. Although echocardiography and computed tomographic angiography (CTA) provide valuable diagnostic and anatomical information, the hemodynamic consequences of PS remain incompletely characterized. This study describes patient-specific pulmonary artery hemodynamics in dogs with and without PS using computational fluid dynamics (CFD). Contrast-enhanced CTA and echocardiographic data from five dogs with PS and five control dogs without PS were used to reconstruct three-dimensional pulmonary artery geometries and generate patient-specific CFD models. Pressure drop (Δp), blood flow velocity, mean wall shear stress (WSS), time-averaged WSS (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), and pulmonary artery resistance were quantified and compared between groups. Dogs with PS exhibited markedly increased transvalvular pressure gradients, peak flow velocities, and pulmonary artery resistance, together with high-velocity jets and localized post-stenotic recirculation that were absent in control dogs. Mean WSS and TAWSS tended to be higher in the PS group, whereas OSI values were similar between groups. In contrast, RRT was significantly lower (