Trial reportActa anaesthesiologica Scandinavica2026
Ephedrine for Reducing Onset Time of Rocuronium in Elderly Patients: A Randomised Study.
Trial report in Acta anaesthesiologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06681662 (A Blinded Randomized Study of Ephedrine 0.15 Mg/kg for Reducing Onset Time of Rocuronium 0.6 Mg/kg in Elderly Patients), which is not on this map. Not yet cited in PubMed.
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A Blinded Randomized Study of Ephedrine 0.15 Mg/kg for Reducing Onset Time of Rocuronium 0.6 Mg/kg in Elderly Patients (≥ 80 Years)
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11 authors.
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Abstract
introductionOnset time of rocuronium is prolonged in elderly patients compared to younger patients. Ephedrine reduces onset time of rocuronium in younger adults, but in elderly patients, the effect of ephedrine on onset time of rocuronium has not been investigated. The aim of this study was to determine the onset time of rocuronium 0.6 mg kg
methodsWe included patients aged ≥ 80 years with American Society of Anesthesiologists physical health Classes I-III scheduled for surgery under total intravenous anaesthesia with rocuronium. Patients were randomised to administration of ephedrine 0.15 mg kg
resultsForty-four patients were allocated to receive ephedrine and 43 patients to receive saline, but the primary endpoint could only be analysed in 38 and 37, respectively. Time to TOF 0 was 134 s (IQR, 107 to 180) in the ephedrine group compared to 139 s (IQR, 121 to 185) in the placebo group (p = 0.60), difference 9 s (95% CI, -14 to 31). Change in MAP was 4 mmHg (SD 21) in the ephedrine group compared to -6 mmHg (SD 22) in the placebo group (p = 0.03), difference 10 mmHg (95% CI 1 to 20). Cardiac arrythmias occurred more often in the ephedrine group compared to the placebo group (p < 0.001). No difference was found in intubating conditions or occurrence of hoarseness or sore throat after surgery.
conclusionNo reduction was found in onset time of rocuronium 0.6 mg kg EDITORIAL COMMENT: Ephedrine intravenous treatment, which can be given around the time of anesthesia induction and muscle relaxant administration, is thought to shorten rocuronium effect onset time for some patients. In this study, this was tested in an elderly cohort, in a blinded trial compared to a placebo treatment. Ephedrine was noted to have predictable cardiovascular effects, but did not have an effect on rocuronium onset time in this cohort.
trial registrationNCT06681662.
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