Evidence map›Paper›PMID 42791586›Full record

ReviewStem cell research & therapy2026

The role and mechanisms of mesenchymal stem cells in postoperative cognitive dysfunction via immune network regulation.

Xuehao Liu, Chengran Wang, Lizheng Huang, Haiqi Song, Shanshan Yu, Fanglei Han, Jinlan Jiang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuehao Liu *Department of Anesthesiology of China-Japan Union Hospital, Jilin University, No.126, Xiantai Street, Economic Development Zone, Changchun City, Changchun, Jilin Province, 130033, China.
Chengran Wang *Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Lizheng HuangDepartment of Anesthesiology of China-Japan Union Hospital, Jilin University, No.126, Xiantai Street, Economic Development Zone, Changchun City, Changchun, Jilin Province, 130033, China.
Haiqi SongDepartment of Anesthesiology of China-Japan Union Hospital, Jilin University, No.126, Xiantai Street, Economic Development Zone, Changchun City, Changchun, Jilin Province, 130033, China.
Shanshan YuDepartment of Anesthesiology of China-Japan Union Hospital, Jilin University, No.126, Xiantai Street, Economic Development Zone, Changchun City, Changchun, Jilin Province, 130033, China.
Fanglei HanDepartment of Anesthesiology of China-Japan Union Hospital, Jilin University, No.126, Xiantai Street, Economic Development Zone, Changchun City, Changchun, Jilin Province, 130033, China. vku@jlu.edu.cn.
Jinlan JiangScientific Research Center of China-Japan Union Hospital, Jilin University, No.126, Xiantai Street, Economic Development Zone, Changchun City, Changchun, Jilin Province, 130033, China. jiangjinlan@jlu.edu.cn.

Funding

Jilin Provincial Natural Science Foundation General Program YDZJ202501ZYTS109
6 · The paper itself

Abstract

Postoperative cognitive dysfunction (POCD) is a common neurological complication in elderly patients after surgery. Its pathophysiology is complex. Neuroinflammation, oxidative stress, and immune imbalance are all involved in this process. These changes can affect postoperative recovery and reduce patients' quality of life. As population aging continues to increase, the prevention and treatment of POCD have become important clinical issues. In recent years, mesenchymal stem cells (MSCs) have attracted attention in neurological diseases because of their immunomodulatory and tissue healing abilities. Current studies suggest that MSCs may relieve neuroinflammation, protect neurons, and improve cognitive function by regulating the immune network. This regulation includes modulating T cell function, promoting macrophage polarization toward an anti-inflammatory phenotype, and maintaining cytokine balance. However, the mechanisms by which MSCs act in POCD have not been fully clarified. Their clinical application also faces several challenges, including transplantation efficiency, long-term safety, and individualized treatment design. Therefore, this review summarizes how MSCs may intervene in POCD through immune network regulation. This review also aims to provide a theoretical basis and possible research directions for future studies in this field.

Indexed as

Mesenchymal Stem Cell TransplantationPostoperative Cognitive ComplicationsAgedAged, 80 and overHumansImmunomodulationMesenchymal Stem CellsQuality of LifeArtificial intelligenceImmune regulationMesenchymal stem cellsPostoperative cognitive dysfunction

Identifiers

PMID42791586
PMCPMC13615578

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.