Observational studyBMC pharmacology & toxicology2026
Association of elevated linezolid trough concentrations with hyperlactatemia in elderly patients: a multicenter observational study in China.
Observational study in BMC pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
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Abstract
backgroundThe association between hyperlactatemia (HLA) and linezolid concentrations in elderly patients remains poorly understood. This study aimed to explore the associations among linezolid trough concentrations, HLA, and clinical outcomes in elderly patients.
methodsElderly patients receiving linezolid treatment at four tertiary hospitals in Beijing between May 2021 and June 2023 were enrolled. Linezolid concentrations and arterial lactate levels were dynamically monitored, and risk factors for HLA and mortality were analyzed to develop a clinical prediction model.
resultsA total of 231 patients were studied, among whom 116 (50.2%) developed HLA. The median average trough concentration (C
conclusionElevated linezolid concentration was independently associated with higher arterial lactate levels, and was exploratorily associated with 30-day mortality in elderly patients. Given the observational design and the limited number of events, these findings should be considered hypothesis-generating. Routine combined monitoring of linezolid concentration and arterial lactate is recommended to guide timely dosage adjustment and reduce adverse outcomes. CLINICAL
trial registrationChinese Clinical Trial Registry (trial registration number: ChiCTR2100045707; April 23, 2021).
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