Trial reportCritical care (London, England)2026
Indirect calorimetry-guided nutrition during weaning from prolonged mechanical ventilation: a double-blind randomized controlled trial.
Trial report in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04825717 (A Randomized Controlled Trial to Examine the Efficacy of a Calorimetry Guided Nutritional Plan vs. the Recommended Daily Intake Guided Nutritional Plan in Weaning Chronically Ventilated Patients), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial to Examine the Efficacy of a Calorimetry Guided Nutritional Plan vs. the Recommended Daily Intake Guided Nutritional Plan in Weaning Chronically Ventilated Patients
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
purposeTo determine whether indirect calorimetry (IC)-guided nutritional prescriptions improve weaning success and time to liberation from prolonged mechanical ventilation (PMV) compared with predictive-equation-guided feeding.
methodsIn this double-blind randomized controlled trial conducted at Reuth Tel-Aviv Rehabilitation Hospital (Nov 2019-Apr 2023), with 1-year follow-up, adults ventilated ≥ 21 days were randomized to receive IC-guided energy targets or predictive-equation-guided feeding. Primary outcomes were successful weaning (≥ 7 consecutive days of spontaneous breathing) and time to successful weaning. Secondary outcomes included number of weaning cycles and 1-year mortality. Metabolic/nutritional safety parameters were recorded. Analyses followed the intention-to-treat principle, with additional per-protocol analyses. Time-to-event outcomes were evaluated using Kaplan-Meier estimates and Cox proportional hazards models.
resultsAmong 211 randomized patients (111 IC; 100 control), successful weaning was achieved in 58% of the IC arm and 50% of the control arm (absolute difference 8%; p = 0.33). Median time to successful weaning was 27 vs. 31 days, respectively (p = 0.58). One-year mortality was 48% in the IC arm and 56% in the control arm (absolute difference of -8%, 95%CI: -21.2%, 5.5%; p = 0.29). In a post hoc analysis of the per-protocol cohort (n = 198), a smaller difference between measured energy expenditure and delivered energy intake (energy-gap) was independently associated with a higher likelihood of successful weaning (HR = 1.02 per 50-kcal/day reduction in the energy-gap; 95%CI: 1.00, 1.05; p = 0.02). IC-guided feeding resulted in closer alignment between measured energy expenditure and delivered energy intake and reduced the tendency toward overfeeding observed with predictive-equation-based prescriptions. Successful weaning was independently associated with lower one-year mortality (HR = 0.54; 95%CI: 0.36-0.82), adjusting for study arm.
conclusionThe observed rates of successful weaning and one-year survival were numerically higher, and median time to liberation was shorter, with IC-guided nutrition than with predictive-equation-guided feeding, although between-group differences were not statistically significant. Closer alignment between measured energy expenditure and delivered energy intake was independently associated with successful weaning. These findings support further evaluation of energy delivery guided by measured energy expenditure in adequately powered multicenter trials.
trial registrationClinicalTrials.gov identifier NCT04825717. Registered March 15, 2021.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.