Trial reportBMC ophthalmology2026
Quantitative assessment of radial peripapillary capillary plexus vessel density after retrobulbar block in cataract surgery: a randomized controlled trial.
Trial report in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the effect of retrobulbar anesthesia administered before phacoemulsification on radial peripapillary capillary (RPC) plexus vessel density (VD) using optical coherence tomography angiography (OCTA).
methodsIn this prospective randomized comparative study, 72 consecutive patients undergoing phacoemulsification were randomly assigned to topical anesthesia (n = 36) or retrobulbar anesthesia (n = 36). OCTA imaging was performed preoperatively and repeated at postoperative week 1 and month 1. En face OCTA scans centered on the optic nerve head (4.5 × 4.5 mm) were used to quantify RPC plexus VD automatically using AngioAnalytics™ software. The primary outcome was change in RPC VD over time. Between-group and longitudinal comparisons were performed, including repeated-measures analysis to evaluate group-by-time interactions.
resultsNo significant changes in RPC plexus VD were observed within either group at postoperative week 1 or month 1 compared with baseline (all p > 0.05). Likewise, no significant differences were detected between the topical and retrobulbar anesthesia groups at any evaluated time point or in the magnitude of VD change from baseline to month 1 (all p > 0.05). Effect size analyses demonstrated only small between-group differences, and all corresponding 95% confidence intervals included zero. Repeated-measures analysis revealed no significant group-by-time interaction for any RPC VD parameter (all p > 0.05).
conclusionRetrobulbar anesthesia was not associated with detectable persistent changes in RPC plexus VD at postoperative week 1 or month 1 after uncomplicated phacoemulsification. No clinically meaningful differences in RPC VD were observed between retrobulbar and topical anesthesia. Further studies incorporating earlier postoperative OCTA assessments are warranted to evaluate potential transient vascular effects.
trial registrationISRCTN Registry, ISRCTN13084070. Registered on 26 June 2026; retrospectively registered.
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