Evidence map›Paper›PMID 42791395›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Acquired paroxysmal dysarthria-ataxia syndrome: A systematic review of clinical and MRI findings.

Krzysztof Smolik, Pedro Fraiman, João Claudio Urbano, Rodrigo Alencar, Maria Chiara Bassi, Annalisa Gessani, Sara Montepietra, Manuela Napoli, Francesco Cavallieri, Franco Valzania and 2 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Krzysztof Smolik *Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Modena, Italy.
Pedro Fraiman *Departamento de Neurologia, Universidade Federal do Rio Grande do Norte, Hospital Universitário Onofre Lopes, Natal, RN, Brazil.
João Claudio UrbanoDepartamento de Neurologia, Universidade Federal do Rio Grande do Norte, Hospital Universitário Onofre Lopes, Natal, RN, Brazil.
Rodrigo AlencarDepartamento de Neurologia, Universidade Federal do Rio Grande do Norte, Hospital Universitário Onofre Lopes, Natal, RN, Brazil.
Maria Chiara BassiMedical Library, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy.
Annalisa GessaniDepartment of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Modena, Italy.
Sara MontepietraNeurology Unit, Neuromotor & Rehabilitation Department, Azienda USL-IRCCS of Reggio Emilia, Viale Risorgimento 80, Reggio Emilia, Reggio Emilia, 42123, Italy.
Manuela NapoliNeuroradiology Unit, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy.
Francesco CavallieriNeurology Unit, Neuromotor & Rehabilitation Department, Azienda USL-IRCCS of Reggio Emilia, Viale Risorgimento 80, Reggio Emilia, Reggio Emilia, 42123, Italy. francesco.cavallieri@ausl.re.it.ORCID http://orcid.org/0000-0001-5836-1982
Franco ValzaniaNeurology Unit, Neuromotor & Rehabilitation Department, Azienda USL-IRCCS of Reggio Emilia, Viale Risorgimento 80, Reggio Emilia, Reggio Emilia, 42123, Italy.
Elena MoroMovement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble Alpes University, Grenoble, France.
Clecio Godeiro JuniorDepartamento de Neurologia, Universidade Federal do Rio Grande do Norte, Hospital Universitário Onofre Lopes, Natal, RN, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paroxysmal dysarthria-ataxia syndrome (PDAS) is a rare neurological syndrome initially described in Multiple Sclerosis (MS) and subsequently reported in other conditions. This systematic review focuses on acquired forms of PDAS associated with structural or immune-mediated aetiologies. After screening 3802 articles, 25 studies (31 patients) were included. Twenty-two patients (71%) were male, and the mean age of PDAS onset was 52 years. The most frequent diagnosis was MS, observed in 12 patients (39%), followed by anti-contactin associated protein receptor 2 encephalitis in 6 cases (19%). Lesions were most commonly located in the midbrain, reported in 20 patients (65%). Both the duration and frequency of PDA episodes varied greatly. Outcomes were favorable, with complete resolution of symptoms after pharmacological treatment in 29 patients (93%). Treatment mainly consisted of antiepileptic drugs (AEDs), most commonly carbamazepine, used in 14 patients (45%). These findings show that PDAS is not exclusively associated with MS and that, when treated, its prognosis is generally very good.

Indexed as

AtaxiaDysarthriaBrainHumansMagnetic Resonance ImagingAnti-CASPR2Episodic ataxiaMidbrainMultiple sclerosisParoxysmal dysarthria and ataxiaParoxysmal symptoms

Identifiers

PMID42791395

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.