Evidence map›Paper›PMID 42791388›Full record

ArticleNature cancer2026

Stroke drives glioma progression through the emergence of tumor-associated astrocytes with reduced Ca

Qi Ye, Christine Madamba, Junsung Woo, Tiffany J Choy, Kate F Wheeler, Jiangshan Zhan, Carlo D Cristobal, Catalina Spjut, Donghui Shin, Juyeon Jo and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Qi Ye *Department of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Christine Madamba *Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Junsung WooCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Tiffany J ChoyJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6501-2123
Kate F WheelerJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Jiangshan ZhanDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Carlo D CristobalJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Catalina SpjutDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Donghui ShinDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.ORCID http://orcid.org/0009-0002-8926-5082
Juyeon JoDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Roshan R AilaniJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Joshua SmithDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Khatri LathaCenter for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Akdes Serin HarmanciJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6374-9041
Hari Krishna YalamanchiliDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Marco GalloDepartment of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-8451-8207
Kyuson YunDepartment of Neurology, Houston Methodist Research Institute, Houston, Texas, USA.ORCID http://orcid.org/0000-0003-2253-4153
Yana K ReshetnyakPhysics Department, University of Rhode Island, Kingston, RI, USA.
Eunhee KimVivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Yongsoo KimDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.ORCID http://orcid.org/0000-0002-4277-0279
Ganesh RaoCenter for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Benjamin DeneenCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-6335-1081
Hyun Kyoung LeeDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA. hyunkyol@bcm.edu.ORCID http://orcid.org/0000-0001-5793-4398

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9M
Establishing Common Coordinate Framework for Quantitative Cell Census in Developing Mouse BrainsRF1MH124605 · NIMH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GEE, JAMES C, KIM, YONGSOO · 2020 to 2020
$3.8M
Astrocyte Transcriptional Dependencies in Brain CircuitsR35NS132230 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Benjamin Deneen · 2023 to 2026
$3.5M
Deciphering the mechanisms of glia development and white matter injuryR01NS110859 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Hyun Kyoung Lee · 2019 to 2026
$3.2M
Deciphering Mechanisms of Astrocyte-BBB Interaction in Normal and Ischemic StrokeR01NS126287 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Hyun Kyoung Lee · 2023 to 2026
$1.9M
National Multiple Sclerosis Society (National MS Society) FG-2407-53793NICHD NIH HHS P50 HD103555NINDS NIH HHS R01 NS110859NINDS NIH HHS R01 NS126287NINDS NIH HHS R35 NS132230U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1K99CA295327U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1F31NS141637U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1F31NS145624U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 2R01NS110859U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS126287U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R35-NS132230U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) RF1MH124605
6 · The paper itself

Abstract

Epidemiological studies suggest that persons with a history of stroke are at increased risk of developing brain tumors, yet the mechanisms linking brain injury to glioma progression remain unclear. Here we show that stroke promotes tumor infiltration into injured brain regions in human and mouse glioma models, accompanied by reduced overall survival. Stroke induces remodeling of the tumor microenvironment, including the emergence of a distinct population of tumor-associated astrocytes (TAAs) with diminished Ca

Indexed as

AstrocytesBrain NeoplasmsCalciumGliomaStrokeAnimalsCalcium SignalingCell Line, TumorDisease Models, AnimalDisease ProgressionFemaleHumansMaleMiceMicrogliaTumor MicroenvironmentCalcium

Identifiers

PMID42791388

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.