Evidence map›Paper›PMID 42791387›Full record

ReviewNature cancer2026

Unraveling the lexicon of complex mutational phenomena in human cancers.

Ting Yang, Erik N Bergstrom, Stanley Clarke, Marcin Imieliński, Ludmil B Alexandrov

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ting YangDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Erik N BergstromDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Stanley ClarkeLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.ORCID http://orcid.org/0000-0002-0285-0549
Marcin ImielińskiLaura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA. l2alexandrov@health.ucsd.edu.ORCID http://orcid.org/0000-0003-3596-4515

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although most mutations found in cancer genomes are randomly distributed, some form complex genomic patterns. Over the past 15 years, genomics studies have systematically uncovered multiple mutational phenomena, assigning several of them evocative Greek terms including kataegis, omikli, kyklonas, chromothripsis, chromoplexy, pyrgo, rigma and tyfonas. These phenomena are associated with distinct, often incompletely understood, molecular mechanisms and have important implications for tumor evolution and clinical outcomes. This Perspective provides a comprehensive lexicon of these mutational phenomena, addressing ambiguities in their definitions and mechanisms while highlighting their diversity, proposed origins and known associations with mutational processes, drug resistance and clinical outcomes.

Identifiers

PMID42791387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.