ArticleSchizophrenia (Heidelberg, Germany)2026
Schizophrenia: temporal imprecision in phase, time, and frequency domains.
Article in Schizophrenia (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Schizophrenia is associated with deficits in input processing, but the underlying neural dynamics of this deficit remain unclear. A recent model proposes temporal imprecision as a basic disturbance driving the input processing deficit. To address the question of whether temporal imprecision affects all three domains of the brain's signal (e.g., phase, time, and frequency) as early as first episode schizophrenia, we analyzed magnetoencephalography (MEG) data from 25 first-episode schizophrenia (FESZ) participants and 24 healthy controls (HC) during a passive auditory oddball task with standard, pitch deviant, and duration deviant tones while watching a silent movie. We quantified temporal precision via (i) intertrial phase coherence (ITPC), (ii) intrinsic neural timescale (INT), and (iii) power spectral density (PSD) heterogeneity. For all three signal domains, we also calculated their temporal variability in sliding windows over the MEG recording. FESZ showed reduced intertrial phase coherence to both deviant tones, with a broader time and frequency range for the duration deviant ITPC reduction. Intrinsic neural timescales were prolonged in FESZ subjects. PSD profiles were more heterogeneous and broader during the auditory task in the FESZ group. FESZ subjects also showed increased temporal variability in all three signal domains across sliding windows. Finally, significant associations were observed between temporal variability in all three signal domains, including their association to impaired duration deviant mismatch negativity amplitude in first episode schizophrenia, whereas these associations were largely absent for healthy participants. We conclude that first-episode schizophrenia shows convergent temporal imprecision at specific time points as well as between time points in all three signal domains including phase, time, and frequency; this is consistent with temporal imprecision as a domain-general basic disturbance of input processing in schizophrenia.
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