Evidence map›Paper›PMID 42791224›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2026

Maternal-Fetal Interplay During Mid-gestation: Inflammatory Biomarker Levels in Maternal Sera, Cord Sera and Placenta.

Dana E Goin, Lin Li, Stephanie L Gaw, Rachel Morello-Frosch, Tracey J Woodruff, Stephanie M Eick, Joshua F Robinson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dana E GoinDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.ORCID https://orcid.org/0000-0002-7557-7977
Lin LiCenter For Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA.
Stephanie L GawCenter For Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA.
Rachel Morello-FroschDepartment of Environmental Science, Policy and Management and School of Public Health, University of California, Berkeley, California, USA.ORCID https://orcid.org/0000-0003-1153-7287
Tracey J WoodruffProgram On Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA.
Stephanie M EickGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-0891-6964
Joshua F RobinsonCenter For Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-2421-4535

Funding

UCSF Environmental Research and Translation for Health Center (EaRTH Center)P30ES030284 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JENNIFER C FUNG, Tracey J. Woodruff · 2020 to 2026
$11.2M
The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's CenterP01ES022841 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, TRACEY J. · 2013 to 2018
$3.9M
Prenatal stress exposures and fetal inflammation during mid-gestationR21HD109723 · NICHD · EMORY UNIVERSITY · PI EICK, STEPHANIE MARIE, ROBINSON, JOSHUA FREDERICK · 2023 to 2024
$450k
National Institute of Child Health and Human Development R21HD109723NICHD NIH HHS R21 HD109723NIEHS NIH HHS P01 ES022841NIEHS NIH HHS P01ES022841NIEHS NIH HHS P30 ES030284NIEHS NIH HHS P30ES030284
6 · The paper itself

Abstract

problemMaternal inflammation is linked to adverse maternal and fetal outcomes, but how maternal inflammation affects fetal inflammation during mid-gestation is not known. METHOD OF STUDY: We measured 20 biomarkers of inflammation, including chemokines, pro-and anti-inflammatory cytokines, and immunomodulatory cytokines, in matched maternal and cord sera and placental tissue collected during the second trimester from a diverse cohort (N = 106). We examined trends in biomarkers across the second trimester using a linear trend test, and compared distributions across sociodemographic groups using a Kruskal-Wallis test. We calculated Spearman correlation coefficients and stratified the correlation matrices by gestational age at sample collection (<20 vs. ≥ 20 gestational weeks).

resultsMost inflammatory biomarkers did not exhibit clear trends with gestational age, except for cord levels of CCL17 and CCL22; both Th2-associated chemokines significantly increased across the second trimester. There were no consistent patterns in biomarker levels across sociodemographic groups. Overall, correlations among maternal, placental and cord biomarkers were stronger before 20 weeks' gestation than in later pregnancy. While correlations between maternal and placental CCL17 declined after 20 weeks, the correlation between placental and cord CCL17 increased during this same period.

conclusionsMaternal and fetal inflammatory responses are more tightly coordinated earlier in the second trimester.

Indexed as

Fetal BloodInflammationMaternal-Fetal ExchangePlacentaAdultBiomarkersChemokine CCL17CytokinesFemaleGestational AgeHumansPregnancyPregnancy Trimester, SecondBiomarkersChemokine CCL17Cytokinescytokinesfetal healthinflammationplacenta

Identifiers

PMID42791224
PMCPMC13614898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.