Evidence map›Paper›PMID 42791030›Full record

Trial reportGeriatrics & gerontology international2026

Does Dosage Drive Durability? A Longitudinal Study on Digital Cognitive Training for Sustained Functional Independence.

Bruno Costa Poltronieri, Cíntia Monteiro Carvalho, Karin Reuwsaat, Maria Eduarda Alves Reis, Ana Carolina Madeira, Thayná de Carvalho Freire, Rogerio Panizzutti

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Geriatrics & gerontology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03911765 (Effect of Digital Cognitive Training on the Functionality of Older Adults With Mild Cognitive Impairment), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03911765 phase1unknown statusnot on this map

Effect of Digital Cognitive Training on the Functionality of Older Adults With Mild Cognitive Impairment (MCI)

TypeinterventionalSponsorUniversidade Federal do Rio de JaneiroRan2019 to 2019Enrolled40ConditionsMild Cognitive Impairment, AgingArmsdigital cognitive training
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bruno Costa PoltronieriInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-2127-0574
Cíntia Monteiro CarvalhoInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-8115-7426
Karin ReuwsaatInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-5061-3591
Maria Eduarda Alves ReisInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0009-0002-3789-9219
Ana Carolina MadeiraInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0009-0007-9108-9053
Thayná de Carvalho FreireInstituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0009-0008-4831-2093
Rogerio PanizzuttiInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-6755-9840

Funding

Computerized cognitive training for schizophrenia in Brazil.R03TW009002 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PANIZZUTTI, ROGERIO, VINOGRADOV, SOPHIA · 2013 to 2015
$176k
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 400455/2012-9FIC NIH HHS R03 TW009002Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) GE-26/110.305/2014John E. Fogarty International Center - National Institutes of Health (NIH) R03TW009002
6 · The paper itself

Abstract

backgroundThis study aimed to investigate whether a higher cumulative dose of digital cognitive training leads to greater and more sustained improvements in cognition and functionality among older adults with Mild Neurocognitive Disorder.

methodsWe recruited participants aged 60 or older with mild neurocognitive disorder to a double-blinded, randomized, stepped wedge clinical trial of digital cognitive training (DCT) compared to an active control group of commercial computer games. Participants were evaluated for functionality and cognition before, after 10 h and 20 h of intervention and in the follow-up.

resultsSixty-seven participants completed DCT and were evaluated. The group that received 20 h of DCT showed significant improvements in functionality and satisfaction, as well as gains in processing speed, verbal fluency, and inhibitory control. The 10 h group also showed improvements in specific areas such as processing speed and recognition. In the 20 h group, the benefits were maintained at 3- and 6-month follow-ups, especially in functionality. DISCUSSION: This study suggests that a higher cumulative dose of DCT may lead to more sustained improvements in functionality performance among older adults with mild neurocognitive disorder. Findings highlight the need for further research to determine optimal training dosage for long-term improvements in cognition and functionality.

trial registrationThe studies reported in the manuscript were pre-registered at ClinicalTrials.gov under the identifier NCT03911765.

Indexed as

CognitionCognitive DysfunctionCognitive TrainingVideo GamesAgedCognitive EnhancementDigital MediaDouble-Blind MethodFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsTreatment Outcomebrain plasticitycognitive trainingfunctionalitymild neurocognitive disorder

Identifiers

PMID42791030
PMCPMC13614873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.