Evidence map›Paper›PMID 42791025›Full record

ArticleRMD open2026

Comparison of four clinical risk prediction models for the diagnosis of giant cell arteritis: results from the ongoing PREDICT-GCA study.

Lukas-Casper Thielmann, Christian Lottspeich, Lilly Juliane Undine Reik, Tobias Wirthmiller, Andreas Nützel, Holger Schneider, Anja Löw, Teresa Henke, Ilaria Prearo, Marc J Mackert and 9 more

Abstract readComparative Study
In one paragraph

Article in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lukas-Casper ThielmannDivision of Vascular Medicine, Department of Medicine IV, LMU University Hospital, Düsseldorf, Germany.
Christian LottspeichInterdisciplinary Sonography Unit, Department of Medicine IV, LMU University Hospital, Munich, Germany.
Lilly Juliane Undine ReikDivision of Vascular Medicine, Department of Medicine IV, LMU University Hospital, Düsseldorf, Germany.
Tobias WirthmillerDivision of Vascular Medicine, Department of Medicine IV, LMU University Hospital, Düsseldorf, Germany.
Andreas NützelDivision of Vascular Medicine, Department of Medicine IV, LMU University Hospital, Düsseldorf, Germany.
Holger SchneiderDivision of Vascular Medicine, Department of Medicine IV, LMU University Hospital, Düsseldorf, Germany.
Anja LöwDivision of Vascular Medicine, Department of Medicine IV, LMU University Hospital, Düsseldorf, Germany.
Teresa HenkeDivision of Vascular Medicine, Department of Medicine IV, LMU University Hospital, Düsseldorf, Germany.
Ilaria PrearoDivision of Vascular Medicine, Department of Medicine IV, LMU University Hospital, Düsseldorf, Germany.
Marc J MackertDepartment of Ophthalmology, LMU University Hospital, Munich, Germany.ORCID http://orcid.org/0000-0003-4473-2812
Siegfried PriglingerDepartment of Ophthalmology, LMU University Hospital, Munich, Germany.
Heiko SchulzInstitute of Pathology, LMU, Munich, Germany.
Christoph WalzInstitute of Pathology, LMU, Munich, Germany.
Elisabeth Haas-LützenbergerDepartment of Hand, Plastic and Aesthetic Surgery, LMU University Hospital, Munich, Germany.
Christina GebhardtDivision of Rheumatology, Department of Medicine IV, LMU University Hospital, Munich, Germany.
Claus-Jürgen BauerClinic of Internal Medicine III, Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-3152-6550
Valentin S SchäferClinic of Internal Medicine III, Oncology, Hematology, Rheumatology and Clinical Immunology, University Hospital of Bonn, Bonn, Germany.
Hendrik Schulze-KoopsDivision of Rheumatology, Department of Medicine IV, LMU University Hospital, Munich, Germany.ORCID http://orcid.org/0000-0002-1681-491X
Michael CzihalDivision of Vascular Medicine, Department of Medicine IV, LMU University Hospital, Düsseldorf, Germany michael.czihal@med.uni-muenchen.de.ORCID http://orcid.org/0000-0003-4199-6345

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe potential role of structured clinical pretest probability assessment in the diagnostic workup of giant cell arteritis (GCA) is not well defined. PATIENTS AND

methodsWe applied four clinical prediction rules to patients enrolled in the ongoing prospective PREDICT GCA study. All patients underwent temporal artery biopsy in addition to the detailed clinical and sonographic workup. The final diagnosis was based on the 6 months follow-up and ambiguous cases were judged by an independent expert panel. The diagnostic accuracy of the four models was determined using 2×2 contingency tables and receiver operating characteristic analysis. Patients with and without discordant results in different scoring systems were compared using univariate significance tests.

resultsSeventy patients were analysed. The highest diagnostic accuracy (area under the curve (AUC) 0.84) and the highest negative predictive value (NPV, 86.7%) were provided by the Ing

conclusionClinical prediction models for the diagnosis of GCA differ in their diagnostic accuracy. Clinically relevant discordances of individual risk prediction are common. TRIAL REGISTRATION NUMBER: DRKS00031293.

Indexed as

Giant Cell ArteritisAgedAged, 80 and overBiopsyFemaleHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsROC CurveTemporal ArteriesClassificationGiant Cell ArteritisSensitivity and SpecificitySystemic vasculitisVasculitis

Identifiers

PMID42791025
PMCPMC13629985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.