Evidence map›Paper›PMID 42790900›Full record

ArticleBMJ open2026

Artificial intelligence in perioperative pain: a scoping review protocol.

Aniello Alfieri, Valentina Cerrone, Sveva Di Franco, Marco Cascella, Rosario De Feo, Ornella Piazza, Maria Pia Bruno, Marco Fiore

Abstract read
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aniello AlfieriDepartment of Women's, Children's and General and Specialised Surgery, University of Campania "Luigi Vanvitelli", Napoli, Italy.
Valentina CerroneDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.ORCID http://orcid.org/0009-0006-5657-6959
Sveva Di FrancoDepartment of Intensive Care and Anaesthesiology, AORN A. Cardarelli, Napoli, Italy.
Marco CascellaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
Rosario De FeoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
Ornella PiazzaDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy opiazza@unisa.it.ORCID http://orcid.org/0000-0002-0316-5930
Maria Pia BrunoDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
Marco FioreDepartment of Women's, Children's and General and Specialised Surgery, University of Campania "Luigi Vanvitelli", Napoli, Italy.ORCID http://orcid.org/0000-0001-7263-0229

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPerioperative pain is a major determinant of patients' experience and may influence long-term outcomes. Artificial intelligence (AI) is applied to perioperative datasets to predict acute postoperative pain, opioid requirements, analgesic-related adverse events, chronic postsurgical pain and pain trajectories. However, the evidence is dispersed across perioperative phases, clinical outcomes, data modalities and AI methodologies, while the extent to which current models address validation, interpretability, uncertainty and clinical implementation remains unclear. This scoping review protocol aims to characterise the existing evidence on AI applications related to perioperative pain to identify methodological features that affect its clinical credibility and implementation. METHODS AND ANALYSIS: This protocol will follow the Joanna Briggs Institute methodology for scoping reviews and will be reported in line with Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews (PRISMA-ScR) guidance. Eligible studies will include human research evaluating AI methods in relation to pain-related perioperative outcomes, including observational studies, interventional studies and predictive modelling studies. AI approaches include machine learning, deep learning, natural language processing, computer vision, large language models and hybrid or ensemble methods. Searches will be conducted from PubMed/MEDLINE, Embase, the Cochrane Library, medRxiv, arXiv and ClinicalTrials.gov, with supplementary screening of reference lists. Results will be synthesised descriptively. The formal literature searches are planned for September 2026, with completion of study selection, data charting, evidence synthesis and preparation of the final review expected by December 2026. ETHICS AND DISSEMINATION: We will chart ethical aspects reported in included studies, such as governance of retrospective electronic health record use, consent waivers and privacy protections, where available. Findings will be disseminated through submission to a peer-reviewed journal, presentation at scientific meetings and open sharing of search strategies on the Open Science Framework. PROSPERO REGISTRATION NUMBER: This protocol was prospectively registered on the Open Science Framework in March 2026: Cascella M

Indexed as

Artificial IntelligencePain ManagementPostoperative PainHumansResearch DesignScoping Reviews as TopicAdult anaesthesiaArtificial IntelligencePain management

Identifiers

PMID42790900
PMCPMC13630065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.