Evidence map›Paper›PMID 42790138›Full record

ArticleHematology, transfusion and cell therapy2026

The influence of Epstein-Barr virus in the microenvironment of classic Hodgkin lymphoma: A focus on T-cells and macrophages.

Ana Claudia Frota Melo, Valéria Buccheri, Jackson A Barbosa, R S Azevedo, Mario L Marques-Piubelli, McN Zerbini

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Article in Hematology, transfusion and cell therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ana Claudia Frota MeloHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil; Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA. Electronic address: amelo@houstonmethodist.org.
Valéria BuccheriHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Jackson A BarbosaHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
R S AzevedoHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Mario L Marques-PiubelliHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
McN ZerbiniHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prominent immune landscape in classic Hodgkin lymphoma is an essential tool to understand the pathogenesis of the disease.

objectiveThe aim of this study was to evaluate the influence of the Epstein-Barr virus on the frequency and spatial distribution of lymphoid T-cells and macrophages in the immune microenvironment.

methodsPre-treatment lymph node biopsies of 54 Epstein-Barr virus-positive and 91 virus-negative cases of classic Hodgkin lymphoma were studied. Different immune subsets, such as macrophages, T-helper, T-follicular helper, T-regulatory, and T-cytotoxic cells, were evaluated by digital image analysis according to their position in areas close to or distant from neoplastic cells.

resultsWhen compared to virus-negative cases, Epstein-Barr virus-positive classic Hodgkin lymphoma exhibited a higher prevalence of macrophages and CD8

conclusionsCases of Epstein-Barr virus-positive classic Hodgkin lymphoma are related to a cytotoxic predominance, a significant macrophage component, and a decrease in T-follicular helper and T-regulatory cell populations compared to virus-negative cases.

Indexed as

Epstein Barr virusFollicular helper T-cellsHodgkin lymphomaRegulatory cellsTumor macrophagesTumor microenvironment

Identifiers

PMID42790138
PMCPMC13634430

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