Evidence map›Paper›PMID 42789954›Full record

ArticleJournal of food and drug analysis2026

In vitro digestion modifies Lepidium meyenii extract, altering its major glucosinolates, lepidilines, β-carbolines, and gut bacterial growth.

Dominik Tarabasz, Ewa Baranowska-Wójcik, Paweł Szczeblewski, Tomasz Laskowski, Klaudia Gustaw, Marzena Furtak-Niczyporuk, Dominik Szwajgier, Rita Cristina Orihuela-Campos, Henry O Meissner, Julia Borzyszkowska-Bukowska and 1 more

Abstract read
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In one paragraph

Article in Journal of food and drug analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dominik TarabaszDepartment of Pharmacognosy with Medicinal Plants Garden, Medical University of Lublin, 1 Chodzki Str., 20-093, Lublin, Poland.
Ewa Baranowska-WójcikDepartment of Biotechnology, Microbiology and Human Nutrition, Faculty of Food Science and Biotechnology, University of Life Sciences in Lublin, Skromna 8 Street, 20-704, Lublin, Poland.
Paweł SzczeblewskiDepartment of Pharmaceutical Technology and Biochemistry and BioTechMed Centre, Faculty of Chemistry, Gdansk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233, Gdansk, Poland.
Tomasz LaskowskiDepartment of Pharmaceutical Technology and Biochemistry and BioTechMed Centre, Faculty of Chemistry, Gdansk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233, Gdansk, Poland.
Klaudia GustawDepartment of Biotechnology, Microbiology and Human Nutrition, Faculty of Food Science and Biotechnology, University of Life Sciences in Lublin, Skromna 8 Street, 20-704, Lublin, Poland.
Marzena Furtak-NiczyporukChair and Department of Public Health, Medical University of Lublin, 1 Chodzki Str., 20-093, Lublin, Poland.
Dominik SzwajgierDepartment of Biotechnology, Microbiology and Human Nutrition, Faculty of Food Science and Biotechnology, University of Life Sciences in Lublin, Skromna 8 Street, 20-704, Lublin, Poland.
Rita Cristina Orihuela-CamposAcademic Department of Stomatology for Children and Adolescents, Integrated Faculties of Medicine, Stomatology and Nursing, Cayetano Heredia Peruvian University, Av. Honorio Delgado 430, Lima, Peru.
Henry O MeissnerDepartment of Pharmacognosy with Medicinal Plants Garden, Medical University of Lublin, 1 Chodzki Str., 20-093, Lublin, Poland.
Julia Borzyszkowska-BukowskaDepartment of Pharmaceutical Technology and Biochemistry and BioTechMed Centre, Faculty of Chemistry, Gdansk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233, Gdansk, Poland.
Wirginia Kukula-KochDepartment of Pharmacognosy with Medicinal Plants Garden, Medical University of Lublin, 1 Chodzki Str., 20-093, Lublin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tubers of Lepidium meyenii (commonly known as maca) have been used in the Andean cuisine for ages. The study aims to determine the behavior of the extract from the red phenotype of maca in the in vitro gastrointestinal tract model and also to define the overall impact of the extract on the microbiota. Glucosinolates, lepidilines, and a derivative of β-carboline alkaloid, i.e. 1-methyltetrahydro-β-5,6-hydride-carboline-3-carboxylic acid, as representatives of one of the main groups of metabolites were selected for the quantitative analysis after in vitro digestion at every stage of the digestion model. The results showed that lepidilines remained highly stable throughout the digestive simulation, whereas glucosinolates and the β-carboline derivative were substantially degraded, under the influence of the enzymes and bacteria applied in the "large intestine". In addition, the red maca extract exhibited prebiotic activity by promoting the growth of selected lactic acid bacteria, with Lactococcus lactis showing the most pronounced response, suggesting that maca-derived preparations may hold promising potential as ingredients in functional foods and microbiota-targeted nutritional formulations.

Indexed as

BacteriaCarbolinesDigestionGastrointestinal TractGlucosinolatesLepidiumPlant ExtractsHumansCarbolinesGlucosinolatesPlant Extracts

Identifiers

PMID42789954
PMCPMC13592842

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.