ArticleScience advances2026
Specific and efficient translation inhibition-transcription activation resistance module against viruses in plants.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Positive-sense RNA viruses using subgenomic RNAs (sgRNAs) cause severe crop losses, yet this conserved feature has rarely been exploited for antiviral engineering. Here, we constructed a virus-activated synthetic immune circuit, wherein viral sgRNA production drives host defense responses via a translation inhibition-transcription activation (TI-TA) module. An optimized translational repression element (dsBC) minimized basal expression while enabling virus-specific activation of resistance-inducing proteins (RIPs) by cognate viral sgRNA promoters. This circuit functioned against three major sgRNA-producing viruses-pepino mosaic virus (PepMV), tobacco mosaic virus (TMV), and cucumber mosaic virus (CMV)-in
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