In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
28 authors.
Alex ZaufelDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz; Graz, Austria.ORCID 0009-0001-3924-4366 Nunzia PastoreTelethon Institute of Genetics and Medicine (TIGEM); Pozzuoli, Italy; Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy.
Hubert HacklInstitute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-4055-3841 Judith SommerDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz; Graz, Austria.
Dagmar Silbert-WagnerDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz; Graz, Austria.
Jan G HengstlerDepartment of Toxicology, Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Dortmund, Germany.
Brigitte Begher-TibbeDepartment of Toxicology, Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Dortmund, Germany.ORCID 0000-0003-2390-9148 Rudolf StauberDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz; Graz, Austria.ORCID 0000-0002-3687-9331 Dagmar KolbCore Facility, Ultrastructure Analysis, Center for Medical Research, Medical University of Graz, Graz, Austria.
Martin TroetzmuellerCore Facility, Mass Spectrometry, Center for Medical Research, Medical University of Graz, Graz, Austria.ORCID 0000-0003-0545-9892 Benjamin GottschalkGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.ORCID 0000-0001-5588-7698 Chelsea ThorsheimCardiovascular Institute Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-5990-4165 Eva-Lena StangeInstitute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital;,Aachen, Germany.ORCID 0000-0001-8277-0663 Mathias W HornefInstitute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital;,Aachen, Germany.ORCID 0000-0001-6096-9110 Olga Pivovarova-RamichDepartment of Molecular Metabolism and Precision Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.ORCID 0000-0002-3583-8546 Andreas F H PfeifferCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Endocrinology and Metabolism, Berlin, Germany.ORCID 0000-0002-6887-0016 Kylie P MatchettCentre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh BioQuarter, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-8710-7721 Neil C HendersonCentre for Inflammation Research, Institute for Regeneration and Repair, Edinburgh BioQuarter, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-2273-4094 Andrea BallabioTelethon Institute of Genetics and Medicine (TIGEM); Pozzuoli, Italy; Medical Genetics Unit, Department of Medical and Translational Science, Federico II University, Naples, Italy.ORCID 0000-0003-1381-4604 Zoltan AranyCardiovascular Institute Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1368-2453 Christian WolfrumInstitute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
Peter FickertDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz; Graz, Austria.ORCID 0000-0003-0906-4636 Tarek MoustafaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz; Graz, Austria.ORCID 0000-0002-6755-4687 Funding
Wellcome Trust
6 · The paper itselfAbstract
The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal cues to regulate hepatic lipid metabolism with major implications for metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we show that altered hepatic mTORC1-TFEB/TFE3 signaling is associated with coordinated remodeling of bile acid (BA) metabolism during metabolic adaptation. Our data support a model in which cross-talk between mTORC1 and TFEB/TFE3 is associated with divergent regulation of bile acid synthesis and transformation. Depending on the mTORC1 signaling state, changes in hepatic
Indexed as
Adaptation, PhysiologicalBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBile Acids and SaltsLiverMechanistic Target of Rapamycin Complex 1Signal TransductionAnimalsFatty LiverHumansMetabolic ReprogrammingMiceBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBile Acids and SaltsMechanistic Target of Rapamycin Complex 1Tcfe3 protein, mouseTcfeb protein, mouse
Identifiers
PMID42789715
PMCPMC13618816
What OpenQuestion holds
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